Abstract：
Preeclampsia is a pregnancy-specific disease which is characterized by abnormal placentation, endothelial dysfunction, and systemic inflammation. Several studies have shown that the maternal immune system, which is crucial for maintaining the pregnancy by ensuring maternal-fetal-tolerance, is disrupted in preeclamptic patients. Besides different immune cells, immune checkpoint molecules such as the programmed cell death protein 1/programmed death-ligand 1 (PD-1/PD-L1 system) and the T-cell immunoglobulin and mucin domain-containing protein 3/Galectin-9 (TIM-3/Gal-9 system) are key players in upholding the balance between pro-inflammatory and anti-inflammatory signals. Therefore, a clear understanding about the role of these immune checkpoint molecules in preeclampsia is essential. This review discusses the role of these two immune checkpoint systems in pregnancy and their alterations in preeclampsia.
摘要：
子痫前期是一种妊娠特异性疾病，其特征是胎盘异常，内皮功能障碍,和全身性炎症。一些研究表明，母体的免疫系统，这对于通过确保母胎耐受性来维持妊娠至关重要，先兆子痫患者受到破坏。除了不同的免疫细胞,免疫检查点分子,如程序性细胞死亡蛋白1/程序性死亡配体1(PD-1/PD-L1系统)和T细胞免疫球蛋白和含粘蛋白结构域的蛋白3/半乳糖凝集素-9(TIM-3/Gal-9系统)是维持促炎和抗炎信号之间平衡的关键因素.因此,清楚了解这些免疫检查点分子在先兆子痫中的作用至关重要.这篇综述讨论了这两种免疫检查点系统在妊娠中的作用及其在先兆子痫中的变化。
