PDF(Pubmed)
Abstract：
Escalating government and commercial efforts to plan and deploy viable manned near-to-deep solar system exploration and habitation over the coming decades now drives next-generation space medicine innovations. The application of cutting-edge precision medicine, such as brain stimulation techniques, provides powerful clinical and field/flight situation methods to selectively control vagal tone and neuroendocrine-modulated corticolimbic plasticity, which is affected by prolonged cosmic radiation exposure, social isolation or crowding, and weightlessness in constricted operational non-terran locales. Earth-based clinical research demonstrates that brain stimulation approaches may be combined with novel psychotherapeutic integrated memory structure rationales for the corrective reconsolidation of arousing or emotional experiences, autobiographical memories, semantic schema, and other cognitive structures to enhance neuropsychiatric patient outcomes. Such smart cotherapies or countermeasures, which exploit natural, pharmaceutical, and minimally invasive neuroprosthesis-driven nervous system activity, may optimize the cognitive-emotional restructuring of astronauts suffering from space-related neuropsychiatric disease and injury, including mood, affect, and anxiety symptoms of any potential severity and pathophysiology. An appreciation of improved neuropsychiatric healthcare through the merging of new or rediscovered smart theragnostic medical technologies, capable of rendering personalized neuroplasticity training and managed psychotherapeutic treatment protocols, will reveal deeper insights into the illness states experienced by astronauts. Future work in this area should emphasize the ethical role of telemedicine and/or digital clinicians to advance the (semi)autonomous, technology-assisted medical prophylaxis, diagnosis, treatment, monitoring, and compliance of astronauts for elevated health, safety, and performance in remote extreme space and extraterrestrial environments.
摘要：
在未来几十年中，政府和商业努力不断升级，以计划和部署可行的载人近深层太阳系探索和居住，现在正在推动下一代太空医学创新。尖端精准医学的应用,比如大脑刺激技术，提供了强大的临床和现场/飞行情况的方法来选择性地控制迷走神经张力和神经内分泌调节的皮质边缘可塑性，受到长时间宇宙辐射暴露的影响，社会孤立或拥挤，在狭窄的非陆地区域中失重。基于地球的临床研究表明，大脑刺激方法可以与新颖的心理治疗综合记忆结构原理相结合，以纠正唤醒或情绪体验的巩固。自传记忆,语义图式,和其他认知结构，以提高神经精神病患者的预后。这样的智能联合疗法或对策，利用自然，Pharmaceutical,和微创神经假体驱动的神经系统活动，可以优化患有与空间有关的神经精神疾病和伤害的宇航员的认知情绪重构，包括情绪,影响，和任何潜在严重程度和病理生理学的焦虑症状。通过合并新的或重新发现的智能与治疗无关的医疗技术，对改善的神经精神医疗保健的赞赏，能够提供个性化的神经可塑性训练和管理的心理治疗方案，将揭示宇航员经历的疾病状态的更深层次的见解。该领域的未来工作应强调远程医疗和/或数字临床医生的道德作用，以促进（半）自主，技术辅助医学预防，诊断,治疗,监测,以及宇航员对提高健康的依从性，安全,以及在遥远的极端空间和外星环境中的表现。
