Abstract：
We describe a 22-year-old woman (2-gravid) case who was referred to our clinic at 18 weeks of gestation for a placenta with vesicular lesions discovered on prenatal examination routine. An ultrasound exam at 31 weeks of gestation showed numerous vesicular lesions, which gradually augmented as the pregnancy advanced. A live normal-appearing fetus was confirmed by intrauterine growth restriction (IUGR). The maternal serum β-human chorionic gonadotropin level remained in normal ranges. At some point, a multidisciplinary medical consensus considered the termination of the pregnancy, but the patient refused to comply. At 33 weeks of gestation, preterm premature rupture of membranes (pPROM) occurred, and she spontaneously delivered a 1600 g healthy female baby with a good long-term outcome. Placental mesenchymal dysplasia (PMD) was retrospectively diagnosed after confronting the data from ultrasound, chorionic villus sampling (CVS), amniocentesis, pathological examination, and immunohistochemical stain. The lack of sufficient reports of PMD determines doctors to be cautious and reserved, approaching these cases more radically than necessary. We reviewed this disease and searched for all cases of PMD associated with healthy, live newborns.
摘要：
我们描述了一名22岁的女性（2妊娠）病例，该病例在妊娠18周时因产前检查常规中发现的带有水泡性病变的胎盘而被转诊到我们的诊所。妊娠31周时的超声检查显示许多水泡性病变，随着怀孕的进展逐渐增加。通过宫内生长受限（IUGR）证实了一个正常的活胎儿。母体血清β-人绒毛膜促性腺激素水平保持在正常范围内。在某个时候,多学科医学共识认为终止妊娠，但病人拒绝服从.妊娠33周时，早产胎膜早破（pPROM）发生，她自发分娩了一个1600克健康的女婴，长期效果良好。胎盘间充质发育不良（PMD）在面对超声数据后进行回顾性诊断，绒毛膜绒毛取样(CVS)，羊膜穿刺术,病理检查,和免疫组织化学染色。缺乏足够的PMD报告决定了医生的谨慎和保留，比必要更彻底地处理这些案件。我们回顾了这种疾病，并搜索了所有与健康相关的PMD病例，活的新生儿。
