Abstract：
It has been previously reported that the improper prescribing of antibiotic eye drops is common among orthokeratology (ortho-k) practitioners. Guidelines have since been developed and disseminated to improve their understanding and implementation of antibiotic prescriptions. This study aimed to investigate the influence of these guidelines on the knowledge, attitude, and prescribing habits of ortho-k practitioners by means of a questionnaire, which was administered nationwide via an official online account to eye care practitioners (ECPs) involved in ortho-k lens fitting, 548 of whom completed the survey. Differences in characteristics before and after the dissemination of the guidelines and between the groups were explored using χ2 tests. The relationship between prescribing habits and demographics was analyzed using stepwise logistic regression models. The implementation of the guidelines significantly improved the overall prescribing habits of ECPs (p < 0.001), especially for prophylactic antibiotic use before and after ortho-k lens wear (p < 0.001). Most ECPs who prescribed antibiotics properly displayed significantly better knowledge of correct antibiotic use, which in turn affected the compliance in their ortho-k patients (p < 0.001). The ECPs\' occupations (professionals other than ophthalmologists and optometrists, including nurses and opticians), clinical setting (distributor fitting centers), and age (younger than 25 years) were risk factors for the misuse of antibiotics. Although the implementation of the antibiotic guidelines significantly improved overall prescribing habits, some practitioners\' prescribing behavior still needs improvement. A limitation of this study was that all questions were mandatory, requiring ECPs to recall information, and therefore was subjected to selection and recall bias.
摘要：
先前已经报道,抗生素滴眼液的不适当处方在角膜塑形术(ortho-k)从业者中是常见的。此后，已经制定和传播了指南，以提高他们对抗生素处方的理解和实施。本研究旨在调查这些指南对知识的影响，态度,并通过问卷调查的方式规定矫治医生的习惯，这是通过一个官方在线账户在全国范围内管理的，该账户是涉及正交镜片装配的眼部护理从业人员（ECPs），其中548人完成了调查。使用χ2检验探讨了指南传播前后以及组间特征的差异。使用逐步逻辑回归模型分析了处方习惯与人口统计学之间的关系。指南的实施显着改善了ECPs的总体处方习惯（p<0.001），尤其是在佩戴ortho-k镜片之前和之后使用预防性抗生素（p<0.001）。大多数正确开抗生素处方的ECP对正确使用抗生素表现出明显更好的知识，这反过来又影响了他们的正k患者的依从性(p<0.001)。ECPs职业(眼科医生和验光师以外的专业人员，包括护士和眼镜师)，临床设置（分销商装配中心），年龄(小于25岁)是滥用抗生素的危险因素.尽管抗生素指南的实施显着改善了总体处方习惯，一些从业者的处方行为仍需改进。这项研究的局限性在于所有问题都是强制性的，要求ECPs召回信息，因此受到选择和召回偏差的影响。
