Abstract：
Francisella is an intracellular, fastidious, Gram-negative bacterium that is difficult to identify using routine microbiological methods in the laboratory. We studied the isolation of Francisella sp. (strain IDAMR664) from the blood of a patient with anti-interferon-γ (IFN-γ) autoantibodies who presented with septicemia and cholestatic hepatitis. Analysis of the strain IDAMR664 genome sequence revealed the isolate was closely related to the strain GA01-2794 that had been isolated from a human in the USA. In addition, it was clustered with F. orientalis, a fish pathogen. The isolate contained several virulence factors and had Francisella pathogenicity island pattern no. 3.
摘要：
Francisella是细胞内的，挑剔，在实验室中使用常规微生物学方法难以鉴定的革兰氏阴性细菌。我们研究了Francisellasp的隔离。（菌株IDAMR664）来自患有抗干扰素-γ（IFN-γ）自身抗体的患者的血液，该患者患有败血症和胆汁淤积性肝炎。菌株IDAMR664基因组序列的分析显示,该分离株与从美国人分离的菌株GA01-2794密切相关。此外,它聚集了F.Orientalis，一种鱼类病原体。该分离株含有几种毒力因子，具有Francisella致病性岛模式。3.
