PDF(Pubmed)
Abstract：
In this approach, tensiometry and UV-visible techniques are used to determine the effect of cationic gemini and conventional surfactants on tetracaine hydrochloride (TCH), an anesthetic drug. We have estimated micellar, interfacial, and energetic constraints. To gain a deep understanding of their mixed association behavior, the outputs were examined using different theoretical models. The critical micelle concentration for single and mixed amphiphiles was estimated. The cmc values of mixed amphiphiles were found between the individual amphiphiles due to strong attractive interaction (synergism) between the components after mixing. The non-ideal behavior of mixtures was confirmed by the larger values of ideal cmc than the experimental cmc values. The negative values of interaction parameter (β) and values of activity coefficients less than unity indicate strong synergistic interaction between drug and surfactant. The stability of the mixed systems is demonstrated by the negative Gibbs free energy of micellization and excess free energy of micellization. In contrast to a single chain surfactant, a double chain surfactant (gemini) exhibits better interactions with the drug. Spectral measurements (UV-visible spectra) were used to monitor the binding of the drug with surfactant (conventional as well as gemini). Studying these mixed aggregates could help to optimize their compositions and find synergistic properties between TCH monomers and surfactants.
摘要：
在这种方法中，使用张力计和紫外可见技术来确定阳离子双子和常规表面活性剂对盐酸丁卡因（TCH）的影响，麻醉药.我们估计胶束，界面,和充满活力的约束。为了深入了解他们的混合联想行为，使用不同的理论模型检查了输出。估算了单一和混合两亲物的临界胶束浓度。由于混合后组分之间的强吸引相互作用（协同作用），因此在各个两亲物之间发现了混合两亲物的cmc值。混合物的非理想行为通过理想cmc值大于实验cmc值得到证实。相互作用参数（β）的负值和活度系数的值小于一，表明药物与表面活性剂之间具有很强的协同作用。混合体系的稳定性由胶束化的负吉布斯自由能和胶束化的过量自由能证明。与单链表面活性剂相比，双链表面活性剂（双子）表现出更好的相互作用与药物。使用光谱测量(UV-可见光谱)来监测药物与表面活性剂(常规以及双子)的结合。研究这些混合聚集体可以帮助优化它们的组成并发现TCH单体和表面活性剂之间的协同性能。
