Abstract：
BACKGROUND: Patients with psoriatic arthritis (PsA) may develop uveitis, a potentially serious ocular complication. PsA-related uveitis may result in significant morbidity and even vision loss if underdiagnosed or under-treated. We presented a case with long-standing recurrent uveitis and retinal vasculitis successfully managed by fortified systemic immunomodulators for systemic PsA.
METHODS: A 47-year-old woman was referred under the impression of acute anterior uveitis in her right eye in recent one month. Ocular examinations showed panuveitis in both eyes with intense vitreous opacity in her right eye. Fundus fluorescence angiography revealed retinal vasculitis in both eyes. Systemic surveys excluded the possibility of infection but showed an elevated inflammation marker. With intensive immunosuppressive treatment, inflammation resolved and the vision improved.
CONCLUSIONS: Our case highlights not only the importance of intensified systemic therapy in treating PsA-related uveitis but the importance of multidisciplinary collaboration. Recurrent uveitis may be an indicator of disease activity prior to other inflammatory markers.
METHODS: A 47-year-old woman was referred under the impression of acute anterior uveitis in her right eye in recent one month. Ocular examinations showed panuveitis in both eyes with intense vitreous opacity in her right eye. Fundus fluorescence angiography revealed retinal vasculitis in both eyes. Systemic surveys excluded the possibility of infection but showed an elevated inflammation marker. With intensive immunosuppressive treatment, inflammation resolved and the vision improved.
CONCLUSIONS: Our case highlights not only the importance of intensified systemic therapy in treating PsA-related uveitis but the importance of multidisciplinary collaboration. Recurrent uveitis may be an indicator of disease activity prior to other inflammatory markers.
摘要：
背景：银屑病关节炎（PsA）患者可能会发展为葡萄膜炎，潜在的严重眼部并发症.如果未被诊断或治疗不足，PsA相关的葡萄膜炎可能会导致严重的发病率甚至视力丧失。我们介绍了一个长期复发性葡萄膜炎和视网膜血管炎的病例，该病例通过强化的全身性免疫调节剂成功治疗全身性PsA。
方法：最近一个月，一名47岁女性在右眼急性前葡萄膜炎的印象下转诊。眼部检查显示双眼全葡萄膜炎，右眼玻璃体混浊。眼底荧光血管造影显示双眼视网膜血管炎。系统性调查排除了感染的可能性，但显示炎症标志物升高。强化免疫抑制治疗,炎症消退，视力改善。
结论：我们的案例不仅强调了强化全身治疗在治疗PsA相关葡萄膜炎中的重要性，而且强调了多学科合作的重要性。复发性葡萄膜炎可能是其他炎症标志物之前的疾病活动的指标。
方法：最近一个月，一名47岁女性在右眼急性前葡萄膜炎的印象下转诊。眼部检查显示双眼全葡萄膜炎，右眼玻璃体混浊。眼底荧光血管造影显示双眼视网膜血管炎。系统性调查排除了感染的可能性，但显示炎症标志物升高。强化免疫抑制治疗,炎症消退，视力改善。
结论：我们的案例不仅强调了强化全身治疗在治疗PsA相关葡萄膜炎中的重要性，而且强调了多学科合作的重要性。复发性葡萄膜炎可能是其他炎症标志物之前的疾病活动的指标。
