Abstract：
Periodontitis is a diseased condition of the gum which imposes considerable costs on healthcare systems. It progresses further beyond the inflammation of supportive tissues of the teeth, and the collateral damages are closely associated with Alzheimer\'s disease, cardiovascular disease, and diabetes mellitus.
A comprehensive literature review was performed to summarize published studies in English during the period of 1990-2021 to discuss the rationales for developing periodontal vaccine, cost-effectiveness analyses on the prevention of periodontitis, Treponema denticola-based vaccine candidates, as well as immunological mechanisms in animal models.
Preventive strategies against periodontitis may halt the onset of gum inflammation and the consequent chronic diseases. Considering the multi-microbial condition of periodontitis, an ideal periodontal vaccine should target multiple pathological pathways. Preventive approaches compared to surgical treatments evidently have significant impact on the healthcare budget and long-term health of the individuals in different communities. Despite many advances in periodontal vaccine research, there are still significant hurdles to overcome in developing a vaccine. Investment in research and development activities on key periodontal pathogens including Treponema denticola and Porphyromonas gingivalis in the foreseeable future is a worthy and cost-effective approach for the policymakers to prevent deleterious impacts of periodontitis.
A comprehensive literature review was performed to summarize published studies in English during the period of 1990-2021 to discuss the rationales for developing periodontal vaccine, cost-effectiveness analyses on the prevention of periodontitis, Treponema denticola-based vaccine candidates, as well as immunological mechanisms in animal models.
Preventive strategies against periodontitis may halt the onset of gum inflammation and the consequent chronic diseases. Considering the multi-microbial condition of periodontitis, an ideal periodontal vaccine should target multiple pathological pathways. Preventive approaches compared to surgical treatments evidently have significant impact on the healthcare budget and long-term health of the individuals in different communities. Despite many advances in periodontal vaccine research, there are still significant hurdles to overcome in developing a vaccine. Investment in research and development activities on key periodontal pathogens including Treponema denticola and Porphyromonas gingivalis in the foreseeable future is a worthy and cost-effective approach for the policymakers to prevent deleterious impacts of periodontitis.
摘要：
牙周炎是牙龈的疾病状况,其对医疗保健系统造成相当大的成本。它进一步超出了牙齿支持组织的炎症，附带损害与阿尔茨海默病密切相关，心血管疾病,和糖尿病。
进行了全面的文献综述，以总结1990-2021年期间以英语发表的研究，以讨论开发牙周疫苗的基本原理。预防牙周炎的成本效益分析，基于密螺旋体的候选疫苗，以及动物模型中的免疫机制。
针对牙周炎的预防策略可以阻止牙龈炎症和随之而来的慢性疾病的发作。考虑到牙周炎的多微生物条件，理想的牙周疫苗应针对多种病理途径。与手术治疗相比，预防方法显然对不同社区中个人的医疗保健预算和长期健康具有重大影响。尽管牙周疫苗研究取得了许多进展，开发疫苗仍有重大障碍需要克服。在可预见的未来，投资于关键牙周病原体的研究和开发活动，包括树突密螺旋体和牙龈卟啉单胞菌，对于决策者来说是一种有价值且具有成本效益的方法，以防止牙周炎的有害影响。
进行了全面的文献综述，以总结1990-2021年期间以英语发表的研究，以讨论开发牙周疫苗的基本原理。预防牙周炎的成本效益分析，基于密螺旋体的候选疫苗，以及动物模型中的免疫机制。
针对牙周炎的预防策略可以阻止牙龈炎症和随之而来的慢性疾病的发作。考虑到牙周炎的多微生物条件，理想的牙周疫苗应针对多种病理途径。与手术治疗相比，预防方法显然对不同社区中个人的医疗保健预算和长期健康具有重大影响。尽管牙周疫苗研究取得了许多进展，开发疫苗仍有重大障碍需要克服。在可预见的未来，投资于关键牙周病原体的研究和开发活动，包括树突密螺旋体和牙龈卟啉单胞菌，对于决策者来说是一种有价值且具有成本效益的方法，以防止牙周炎的有害影响。
