Abstract：
<br><b>Introduction:</b> The prevalence of Crohn\'s disease amounts to 5.9 cases per 100,000 population. Complications such as intestinal strictures usually occur within a long course of Crohn\'s disease. Intestinal resection for stricture does not prevent a stricture recurrence and the need for repeated resections, which in turn leads to the formation of short intestine syndrome. The advantage of endoscopic balloon dilatation is organ preservation and a quick clinical therapeutic effiect. However, the frequency of recurrences after conventional endoscopic balloon dilatation of the intestinal stricture in Crohn\'s disease is still at a relatively high level and amounts to 59%, which justifies the need to improve the endoscopic dilatation technique.</br> <br><b>Aim:</b> The aim of this study to improve the treatment effectiveness for intestinal strictures in Crohn\'s disease using endoscopic balloon dilatation combined with prednisolone injection in the stricture area.</br> <br><b>Materials and methods:</b> Endoscopic treatment for intestinal strictures in Crohn's disease was performed in 64 patients. Depending on the endoscopic technique, patients were randomized into 2 groups. The first group consisted of 32 (50%) patients who underwent conventional endoscopic balloon dilatation of strictured areas. The second group consisted of 32 (50%) patients in whom an endoscopic balloon dilatation in combination with submucosal injection of prednisolone to the area of stricture after dilatation was performed. Patient groups were comparable in age, sex and length of stricture.</br> <br><b>Results and conclusions:</b> The results showed that endoscopic balloon dilatation with administration of 40 mg of prednisolone in group II patients was more effective compared to conventional balloon dilatation. The recurrence rate was reduced from 34.4% to 9.3%. The risk of recurrence of intestinal stricture in group I during the first year of observation was found to be 4.5 times higher - HR = 4.5 (1.6-12.9); P = 0.010. The effectiveness of advanced endoscopic balloon dilatation for intestinal strictures was confirmed by colonoscopy with patomorphological examination of the intestinal mucosa 6 months after dilation in patients of both groups.</br>.
摘要：
<br><b>简介:</b>克罗恩病的患病率为每10万人口5.9例。肠狭窄等并发症通常发生在克罗恩病的长期病程中。肠切除狭窄并不能防止狭窄复发和需要重复切除，这反过来又导致短肠综合征的形成。内窥镜球囊扩张的优点是器官保存和快速的临床治疗效果。然而,在克罗恩病肠狭窄的常规内镜下球囊扩张后复发的频率仍然处于相对较高的水平，达59％，这证明了改进内窥镜扩张技术的必要性。</br><br<<b>目的：</b>本研究旨在提高克罗恩病肠狭窄区内镜下球囊扩张术联合泼尼松龙注射治疗效果。</br><br><b>材料与方法:</b>对64例克罗恩病患者行内镜治疗。根据内窥镜技术，患者被随机分为2组.第一组由32名（50％）患者组成，他们接受了狭窄区域的常规内窥镜球囊扩张术。第二组由32名（50％）患者组成，其中进行了内窥镜球囊扩张术，并在扩张后将泼尼松龙粘膜下注射到狭窄区域。患者组的年龄相当，性别和狭窄的长度。</br><br><b>结果与结论：</b>结果显示，与常规球囊扩张相比，给予泼尼松龙40mg的内镜下球囊扩张术对II组患者更有效。复发率从34.4%降至9.3%。在观察的第一年中，发现I组肠狭窄复发的风险高4.5倍-HR=4.5（1.6-12.9）；P=0.010。两组患者在扩张后6个月通过结肠镜检查并对肠粘膜进行patom形态学检查证实了先进的内镜下球囊扩张治疗肠狭窄的有效性。</br>.
