In this study, we show through bacterial 16S rRNA gene profiling that numerous features of the oral- and fecal microbial communities differentiate children with and without CRMO.
Notably, communities in diseased children are characterized by a lack of potential probiotic bacteria in the fecal community and an overabundance of known pathobionts in the oral microbial communities. Of special interest is the HACEK group, a set of commonly known oral pathogens that are implicated in the development of several acute and chronic diseases such as osteitis and rheumatoid arthritis. Furthermore, we observe that gut bacterial communities in the diseased children appear to reflect an altered host physiology more strongly than the oral community, which could suggest an oral disease origin followed by propagation and/or responses beyond the oral cavity.
Bacterial communities, in particular the oral microbiota, may serve as an indicator of underlying susceptibility to CRMO, or play a yet undefined role in its development.
在这项研究中,我们通过细菌16SrRNA基因谱分析显示,口腔和粪便微生物群落的许多特征可区分患有和不患有CRMO的儿童。
值得注意的是,患病儿童社区的特征是粪便社区中缺乏潜在的益生菌,而口腔微生物群落中已知的病原体过多。特别感兴趣的是HACEK集团,一组众所周知的口腔病原体,与几种急性和慢性疾病的发展有关,如骨炎和类风湿性关节炎。此外,我们观察到,患病儿童的肠道细菌群落似乎比口腔群落更强烈地反映了宿主生理学的改变,这可能表明口腔疾病的起源,然后传播和/或在口腔外的反应。
细菌群落,特别是口腔微生物群,可以作为对CRMO潜在易感性的指标,或在其发展中发挥尚未确定的作用。