Abstract：
OBJECTIVE: Primary gallbladder neuroendocrine carcinomas (GB-NEC) are malignant neoplasms that remained to be studied. In this study we aimed to summarize their clinicopathological characteristics, effective treatment and prognostic factors for patients with GB-NEC.
METHODS: Patients with GB-NEC admitted to Shanghai Jiao Tong University Affiliated Sixth People\'s Hospital and Renji Hospital, School of Medicine, Shanghai Jiao Tong University from October 2012 to August 2020 were enrolled. Clinicopathological characteristics of our patients and those reported in previous studies were recorded. The Kaplan-Meier method and univariate and multivariate Cox regression analyses were used for survival analysis.
RESULTS: Altogether 15 patients from our hospitals and 47 patients from previous studies were included. A total of 55 patients who underwent surgical resection, including R0 and non-R0 resection, had significantly longer overall survival compared with the other seven patients. A univariate analysis indicated that patients aged 60 years or older, with jaundice, carcinoid syndrome, non-R0 resection, and advanced stage were associated with worse survival. A multivariate analysis showed that patients aged 60 years or older, carcinoid syndrome and non-R0 resection, but not lymphadenectomy and adjuvant chemotherapy, were independently related to reduced survival.
CONCLUSIONS: R0 resection should be the first-line treatment for GB-NEC. Older age, carcinoid syndrome and non-R0 resection are independently associated with reduced survival after surgical resection.
METHODS: Patients with GB-NEC admitted to Shanghai Jiao Tong University Affiliated Sixth People\'s Hospital and Renji Hospital, School of Medicine, Shanghai Jiao Tong University from October 2012 to August 2020 were enrolled. Clinicopathological characteristics of our patients and those reported in previous studies were recorded. The Kaplan-Meier method and univariate and multivariate Cox regression analyses were used for survival analysis.
RESULTS: Altogether 15 patients from our hospitals and 47 patients from previous studies were included. A total of 55 patients who underwent surgical resection, including R0 and non-R0 resection, had significantly longer overall survival compared with the other seven patients. A univariate analysis indicated that patients aged 60 years or older, with jaundice, carcinoid syndrome, non-R0 resection, and advanced stage were associated with worse survival. A multivariate analysis showed that patients aged 60 years or older, carcinoid syndrome and non-R0 resection, but not lymphadenectomy and adjuvant chemotherapy, were independently related to reduced survival.
CONCLUSIONS: R0 resection should be the first-line treatment for GB-NEC. Older age, carcinoid syndrome and non-R0 resection are independently associated with reduced survival after surgical resection.
摘要：
目的：原发性胆囊神经内分泌癌（GB-NEC）是恶性肿瘤，尚待研究。在这项研究中，我们旨在总结他们的临床病理特征，GB-NEC患者的有效治疗和预后因素。
方法：上海交通大学附属第六人民医院和仁济医院收治的GB-NEC患者，医学院,上海交通大学于2012年10月至2020年8月入学。记录了我们患者的临床病理特征以及先前研究中报道的特征。使用Kaplan-Meier方法以及单变量和多变量Cox回归分析进行生存分析。
结果：共包括来自我们医院的15名患者和来自先前研究的47名患者。共有55例患者接受了手术切除,包括R0和非R0切除，与其他7例患者相比，患者的总生存期明显更长。单因素分析表明，60岁或以上的患者，黄疸,类癌综合征,非R0切除,晚期与较差的生存率有关。多变量分析显示，60岁或以上的患者，类癌综合征和非R0切除，但不是淋巴结清扫术和辅助化疗,与生存率降低独立相关。
结论：R0切除应是GB-NEC的一线治疗方法。年纪大了,类癌综合征和非R0切除与手术切除后生存率降低独立相关.
方法：上海交通大学附属第六人民医院和仁济医院收治的GB-NEC患者，医学院,上海交通大学于2012年10月至2020年8月入学。记录了我们患者的临床病理特征以及先前研究中报道的特征。使用Kaplan-Meier方法以及单变量和多变量Cox回归分析进行生存分析。
结果：共包括来自我们医院的15名患者和来自先前研究的47名患者。共有55例患者接受了手术切除,包括R0和非R0切除，与其他7例患者相比，患者的总生存期明显更长。单因素分析表明，60岁或以上的患者，黄疸,类癌综合征,非R0切除,晚期与较差的生存率有关。多变量分析显示，60岁或以上的患者，类癌综合征和非R0切除，但不是淋巴结清扫术和辅助化疗,与生存率降低独立相关。
结论：R0切除应是GB-NEC的一线治疗方法。年纪大了,类癌综合征和非R0切除与手术切除后生存率降低独立相关.
