PDF(Pubmed)
Abstract：
Coronavirus disease is caused by the SARS-CoV-2 virus. The virus first appeared in Wuhan (China) in December 2019 and has spread globally. Till now, it affected 269 million people with 5.3 million deaths in 224 countries and territories. With the emergence of variants like Omicron, the COVID-19 cases grew exponentially, with thousands of deaths. The general symptoms of COVID-19 include fever, sore throat, cough, lung infections, and, in severe cases, acute respiratory distress syndrome, sepsis, and death. SARS-CoV-2 predominantly affects the lung, but it can also affect other organs such as the brain, heart, and gastrointestinal system. It is observed that 75 % of hospitalized COVID-19 patients have at least one COVID-19 associated comorbidity. The most common reported comorbidities are hypertension, NDs, diabetes, cancer, endothelial dysfunction, and CVDs. Moreover, older and pre-existing polypharmacy patients have worsened COVID-19 associated complications. SARS-CoV-2 also results in the hypercoagulability issues like gangrene, stroke, pulmonary embolism, and other associated complications. This review aims to provide the latest information on the impact of the COVID-19 on pre-existing comorbidities such as CVDs, NDs, COPD, and other complications. This review will help us to understand the current scenario of COVID-19 and comorbidities; thus, it will play an important role in the management and decision-making efforts to tackle such complications.
摘要：
冠状病毒病是由SARS-CoV-2病毒引起的。该病毒于2019年12月首次出现在武汉（中国），并已在全球传播。到现在为止,它影响了224个国家和地区的2.69亿人，530万人死亡。随着Omicron等变体的出现，COVID-19病例呈指数级增长，数千人死亡。COVID-19的一般症状包括发烧，喉咙痛,咳嗽,肺部感染,and,在严重的情况下，急性呼吸窘迫综合征,脓毒症,和死亡。SARS-CoV-2主要影响肺部，但它也会影响其他器官，如大脑，心,和胃肠系统。据观察，75%的住院COVID-19患者患有至少一种COVID-19相关的共病。最常见的合并症是高血压，NDS,糖尿病,癌症,内皮功能障碍,和CVD。此外，老年患者和既往复药患者的COVID-19相关并发症恶化。SARS-CoV-2还会导致坏疽等高凝问题，中风,肺栓塞,以及其他相关并发症。这篇综述旨在提供关于COVID-19对心血管疾病等现有合并症影响的最新信息，NDS,COPD,和其他并发症。这篇综述将帮助我们了解COVID-19和合并症的现状；因此，它将在解决此类并发症的管理和决策工作中发挥重要作用。
