Abstract：
Mesenchymal stem cells (MSCs) have emerged as a promising therapeutic approach for diverse diseases and injuries. The biological and clinical advantages of human fetal MSCs (hfMSCs) have recently been reported. In terms of promising therapeutic approaches for diverse diseases and injuries, hfMSCs have gained prominence as healing tools for clinical therapies. Therefore, this review assesses not the only biological advantages of hfMSCs for healing human diseases and regeneration, but also the research evidence for the engraftment and immunomodulation of hfMSCs based on their sources and biological components. Of particular clinical relevance, the present review also suggests the potential therapeutic feasibilities of hfMSCs for musculoskeletal disorders, including osteoporosis, osteoarthritis, and osteogenesis imperfecta.
摘要：
间充质干细胞（MSC）已成为多种疾病和损伤的有希望的治疗方法。最近已经报道了人胎儿MSCs(hfMSCs)的生物学和临床优势。就各种疾病和损伤的有希望的治疗方法而言，hfMSC作为临床治疗的治愈工具已经获得了突出的地位。因此,这篇综述不仅评估了hfMSCs用于治疗人类疾病和再生的唯一生物学优势，而且是基于hfMSCs来源和生物成分的移植和免疫调节的研究证据。特别与临床相关，本综述还表明，hfMSCs对肌肉骨骼疾病的潜在治疗可行性，包括骨质疏松症,骨关节炎,和成骨不全症。
