Abstract：
BACKGROUND: Obstructive sleep apnea (OSA) is associated with increases in QT interval corrected for heart rate (QTc interval) and QT variability index (QTVI) and sleep bruxism (SB) is prevalent in OSA patients.
OBJECTIVE: To examine whether QTc interval and QT variability were changed during episodes of rhythmic masticatory muscle activities (RMMAs)/SB in SB patients with and without OSA.
METHODS: The RR and QTc intervals, and QTVI during RMMAs with or without accompanied limb movements (RMMAs/LMs) in 10 normal controls and 10 SB patients without OSA and during apneic and recovery periods of OSA in 10 SB patients with OSA were analysed.
RESULTS: In the SB patients without OSA and controls, QTc intervals and QTVI were significantly increased during RMMAs/LMs compared with those during the 10 s periods (from 10th to 20th s) before the onset and after the offset of RMMAs/LMs, and significantly increased during RMMAs/LMs with awakenings compared with those with microarousals and no arousals. In addition, QTc interval and QTVI were positively correlated with the duration of RMMAs/LMs. Moreover, in the SB patients with OSA, QTc interval and QTVI during the recovery period of OSA events were significantly longer and higher than those during the apneic period regardless of accompanied RMMAs/LMs, and QTc interval and QTVI during the apneic and recovery periods accompanied with RMMAs/LMs were significantly longer and higher than those without accompanied RMMAs/LMs.
CONCLUSIONS: OSA and RMMAs/LMs events were associated with longer QTc intervals and higher QTVI, and RMMAs/LMs might contribute to these changes associated with OSA events accompanied with RMMAs/LMs.
OBJECTIVE: To examine whether QTc interval and QT variability were changed during episodes of rhythmic masticatory muscle activities (RMMAs)/SB in SB patients with and without OSA.
METHODS: The RR and QTc intervals, and QTVI during RMMAs with or without accompanied limb movements (RMMAs/LMs) in 10 normal controls and 10 SB patients without OSA and during apneic and recovery periods of OSA in 10 SB patients with OSA were analysed.
RESULTS: In the SB patients without OSA and controls, QTc intervals and QTVI were significantly increased during RMMAs/LMs compared with those during the 10 s periods (from 10th to 20th s) before the onset and after the offset of RMMAs/LMs, and significantly increased during RMMAs/LMs with awakenings compared with those with microarousals and no arousals. In addition, QTc interval and QTVI were positively correlated with the duration of RMMAs/LMs. Moreover, in the SB patients with OSA, QTc interval and QTVI during the recovery period of OSA events were significantly longer and higher than those during the apneic period regardless of accompanied RMMAs/LMs, and QTc interval and QTVI during the apneic and recovery periods accompanied with RMMAs/LMs were significantly longer and higher than those without accompanied RMMAs/LMs.
CONCLUSIONS: OSA and RMMAs/LMs events were associated with longer QTc intervals and higher QTVI, and RMMAs/LMs might contribute to these changes associated with OSA events accompanied with RMMAs/LMs.
摘要：
背景：阻塞性睡眠呼吸暂停（OSA）与经心率校正的QT间期（QTc间期）和QT变异性指数（QTVI）增加相关，睡眠磨牙症（SB）在OSA患者中普遍存在。
目的：研究是否在有或没有OSA的SB患者的节律性咀嚼肌活动（RMMA）/SB发作期间QTc间期和QT变异性发生改变。
方法：RR和QTc间隔，分析了10名正常对照组和10名没有OSA的SB患者在有或没有伴随肢体运动（RMMAs/LM）的RMMA期间的QTVI，以及10名SBOSA患者在OSA的呼吸暂停和恢复期的QTVI。
结果：在没有OSA的SB患者和对照组中，与RMMA/LMs开始之前和之后的10s期间（从10到20s）相比，RMMA/LMs期间的QTc间隔和QTVI显着增加，与微觉醒和无觉醒的RMMA/LMs相比，觉醒的RMMA/LMs显着增加。此外,QTc间期和QTVI与RMMA/LMs的持续时间呈正相关。在SBOSA患者中，OSA事件恢复期的QTc间期和QTVI明显长于和高于呼吸暂停期，无论是否伴有RMMA/LMs，在伴有RMMA/LMs的呼吸暂停和恢复期的QTc间期和QTVI明显长于和高于没有伴有RMMA/LMs的那些。
结论：OSA和RMMA/LMs事件与更长的QTc间期和更高的QTVI相关，和RMMA/LM可能有助于与伴随RMMA/LM的OSA事件相关的这些变化。
目的：研究是否在有或没有OSA的SB患者的节律性咀嚼肌活动（RMMA）/SB发作期间QTc间期和QT变异性发生改变。
方法：RR和QTc间隔，分析了10名正常对照组和10名没有OSA的SB患者在有或没有伴随肢体运动（RMMAs/LM）的RMMA期间的QTVI，以及10名SBOSA患者在OSA的呼吸暂停和恢复期的QTVI。
结果：在没有OSA的SB患者和对照组中，与RMMA/LMs开始之前和之后的10s期间（从10到20s）相比，RMMA/LMs期间的QTc间隔和QTVI显着增加，与微觉醒和无觉醒的RMMA/LMs相比，觉醒的RMMA/LMs显着增加。此外,QTc间期和QTVI与RMMA/LMs的持续时间呈正相关。在SBOSA患者中，OSA事件恢复期的QTc间期和QTVI明显长于和高于呼吸暂停期，无论是否伴有RMMA/LMs，在伴有RMMA/LMs的呼吸暂停和恢复期的QTc间期和QTVI明显长于和高于没有伴有RMMA/LMs的那些。
结论：OSA和RMMA/LMs事件与更长的QTc间期和更高的QTVI相关，和RMMA/LM可能有助于与伴随RMMA/LM的OSA事件相关的这些变化。
