Abstract：
The spleen, an important tissue for the immune system, acts as a filter for blood within the immune system. Accumulating evidence suggests that the spleen affects a number of brain functions in health and diseases via immune modulation. Systemic inflammation or chronic social defeat stress (CSDS) can cause splenomegaly in rodents. Interestingly, the new antidepressant arketamine could normalize splenomegaly and depression-like behaviors in CSDS-susceptible mice. A recent study strongly supports the direct connection pathway between the brain and spleen, whereby the spleen can regulate the humoral immune defense by the two brain regions, such as corticotropin-related neurons in the paraventricular nucleus (PVN) and the central nucleus of the amygdala (CeA). Furthermore, afferent and efferent vagus nerve signaling may contribute to brain and spleen communication. In this article, we review recent findings of the brain-spleen axis in health and diseases.
摘要：
脾脏,免疫系统的重要组织，作为免疫系统内血液的过滤器。越来越多的证据表明，脾脏通过免疫调节影响健康和疾病中的许多大脑功能。系统性炎症或慢性社会失败压力（CSDS）可导致啮齿动物脾肿大。有趣的是,新的抗抑郁药阿氯胺酮可以使CSDS易感小鼠的脾肿大和抑郁样行为正常化。最近的一项研究强烈支持大脑和脾脏之间的直接连接途径，脾脏可以调节两个大脑区域的体液免疫防御，例如室旁核（PVN）和杏仁核中央核（CeA）中的促肾上腺皮质激素相关神经元。此外，传入和传出迷走神经信号可能有助于脑和脾的交流。在这篇文章中,我们回顾了脑-脾轴在健康和疾病中的最新发现。
