Abstract：
OBJECTIVE: To compare the physiological and biochemical markers in healthy and periodontitis subjects, and to relate these markers with the periodontal health condition.
METHODS: The case-control study was conducted at the Dow University of Health Sciences, Karachi, from April 2017 to March 2018, and comprised systematically healthy controls and periodontitis cases. Periodontal probing depth, clinical attachment loss, oral hygiene indices, educational status and body mass index were recorded for all the subjects. Serum levels of biochemical markers, including calcium, phosphate and interleukin-6, were also measured. Data was analysed using SPSS 16.
RESULTS: Of the 150 subjects, 75(50%) each were in the case and control groups. The overall mean age was 31.23±3.7 years (range: 22-42 years). The cases had relatively poor oral hygiene indices and educational status compared to the controls (p<0.05). Serum calcium level was lower, whereas mean body mass index was higher in the cases compared to the controls (p<0.05). No significant difference was found in interleukin-6 and phosphate levels (p>0.05). Clinical attachment loss showed significant correlation (p<0.05).
CONCLUSIONS: Low serum calcium and educational levels, higher body mass index and poor oral hygiene were found to be the risk factors for the progression of periodontitis.
METHODS: The case-control study was conducted at the Dow University of Health Sciences, Karachi, from April 2017 to March 2018, and comprised systematically healthy controls and periodontitis cases. Periodontal probing depth, clinical attachment loss, oral hygiene indices, educational status and body mass index were recorded for all the subjects. Serum levels of biochemical markers, including calcium, phosphate and interleukin-6, were also measured. Data was analysed using SPSS 16.
RESULTS: Of the 150 subjects, 75(50%) each were in the case and control groups. The overall mean age was 31.23±3.7 years (range: 22-42 years). The cases had relatively poor oral hygiene indices and educational status compared to the controls (p<0.05). Serum calcium level was lower, whereas mean body mass index was higher in the cases compared to the controls (p<0.05). No significant difference was found in interleukin-6 and phosphate levels (p>0.05). Clinical attachment loss showed significant correlation (p<0.05).
CONCLUSIONS: Low serum calcium and educational levels, higher body mass index and poor oral hygiene were found to be the risk factors for the progression of periodontitis.
摘要：
目的：比较健康和牙周炎受试者的生理生化指标，并将这些标记与牙周健康状况联系起来。
方法：病例对照研究在陶氏健康科学大学进行，卡拉奇,从2017年4月至2018年3月，包括系统健康对照和牙周炎病例。牙周探查深度,临床附着丧失，口腔卫生指数，记录所有受试者的教育状况和体重指数.血清生化标志物水平,包括钙,还测量了磷酸盐和白介素6。使用SPSS16对数据进行分析。
结果：在150名受试者中，病例组和对照组各75例(50%)。总体平均年龄为31.23±3.7岁（范围：22-42岁）。与对照组相比，这些病例的口腔卫生指数和教育状况相对较差（p<0.05）。血清钙水平较低，而病例的平均体重指数高于对照组（p<0.05）。白细胞介素-6和磷酸盐水平无显著差异(p>0.05)。临床附着丧失表现出显著的相关性(p<0.05)。
结论：低血清钙和教育水平，较高的体重指数和不良的口腔卫生是牙周炎进展的危险因素。
方法：病例对照研究在陶氏健康科学大学进行，卡拉奇,从2017年4月至2018年3月，包括系统健康对照和牙周炎病例。牙周探查深度,临床附着丧失，口腔卫生指数，记录所有受试者的教育状况和体重指数.血清生化标志物水平,包括钙,还测量了磷酸盐和白介素6。使用SPSS16对数据进行分析。
结果：在150名受试者中，病例组和对照组各75例(50%)。总体平均年龄为31.23±3.7岁（范围：22-42岁）。与对照组相比，这些病例的口腔卫生指数和教育状况相对较差（p<0.05）。血清钙水平较低，而病例的平均体重指数高于对照组（p<0.05）。白细胞介素-6和磷酸盐水平无显著差异(p>0.05)。临床附着丧失表现出显著的相关性(p<0.05)。
结论：低血清钙和教育水平，较高的体重指数和不良的口腔卫生是牙周炎进展的危险因素。
