PDF(Pubmed)
Abstract：
At a regional and local level, the COVID-19 pandemic has not spread out uniformly and some German municipalities have been particularly affected. The seroepidemiological data from these areas helps estimate the proportion of the population that has been infected with SARS-CoV-2 (seroprevalence), as well as the number of undetected infections and asymptomatic cases. In four municipalities which were especially affected, 2,000 participants will be tested for an active SARS-CoV-2 infection (oropharyngeal swab) or a past infection (blood specimen IgG antibody test). Participants will also be asked to fill out a short written questionnaire at study centres and complete a follow-up questionnaire either online or by telephone, including information on issues such as possible exposure, susceptability, symptoms and medical history. The CORONA-MONITORING lokal study will allow to determine the proportion of the population with SARS-CoV-2 antibodies in four particularly affected locations. This study will increase the accuracy of estimates regarding the scope of the epidemic, help determine risk and protective factors for an infection and therefore also identify especially exposed groups and, as such, it will be crucial towards planning of prevention measures.
摘要：
在区域和地方一级，COVID-19大流行并没有统一蔓延，一些德国城市受到的影响尤为严重。这些地区的血清流行病学数据有助于估计感染SARS-CoV-2（血清阳性率）的人口比例，以及未被发现的感染和无症状病例的数量。在四个受影响特别严重的城市，2,000名参与者将接受活动性SARS-CoV-2感染（口咽拭子）或过去感染（血液样本IgG抗体测试）的测试。参与者还将被要求在研究中心填写简短的书面问卷，并在线或通过电话填写后续问卷，包括可能暴露等问题的信息，磁化率,症状和病史。CORONA-Monitoringlokal研究将允许确定在四个特别受影响的位置中使用SARS-CoV-2抗体的人口比例。这项研究将提高有关流行病范围的估计的准确性，帮助确定感染的风险和保护因素，因此也确定特别暴露的群体，因此，这对制定预防措施至关重要。
