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Abstract：
OBJECTIVE: To compare the oncologic outcomes in patients with cT1N0 tongue squamous cell carcinoma (SCC) who underwent different neck management strategies stratified by sonographic depth of invasion (DOI).
METHODS: The included patients were retrospectively enrolled, and divided into two groups: observation (OBS) and elective neck dissection (END). The regional control (RC) and disease-specific survival (DSS) rates were compared and stratified by sonographic DOI.
RESULTS: The mean sonographic and pathologic DOIs were 3.8 and 3.7 mm, respectively; the two DOIs were significantly correlated (Spearman correlation coefficient 0.974. p <0.001). In patients with sonographic DOI <4.0 mm, the 5-year RC rates were 73 and 89% in the OBS and END groups, respectively, and were not significantly different. However, in patients with sonographic DOI ≥4.0 mm, the 5-year RC rate was significantly different between the OBS (57%) and END (80%) groups (p = 0.031). In patients with sonographic DOI <4.0 mm, the 5-year DSS rates were 79 and 89% in OBS and END groups, respectively, and were not significantly different. However, in patients with sonographic DOI ≥4.0 mm, the 5-year DSS rate was significantly different between the OBS (67%) and END (86%) groups (p = 0.033).
CONCLUSIONS: Sonographic DOI was notably correlated with pathologic DOI. Moreover, there was a significant survival difference between the OBS and END groups in cT1N0 tongue SCC patients with sonographic DOI ≥4.0 mm but not in those with sonographic DOI <4.0 mm. Our study provides a useful method to aid decision-making in the clinical setting for this patient group.
METHODS: The included patients were retrospectively enrolled, and divided into two groups: observation (OBS) and elective neck dissection (END). The regional control (RC) and disease-specific survival (DSS) rates were compared and stratified by sonographic DOI.
RESULTS: The mean sonographic and pathologic DOIs were 3.8 and 3.7 mm, respectively; the two DOIs were significantly correlated (Spearman correlation coefficient 0.974. p <0.001). In patients with sonographic DOI <4.0 mm, the 5-year RC rates were 73 and 89% in the OBS and END groups, respectively, and were not significantly different. However, in patients with sonographic DOI ≥4.0 mm, the 5-year RC rate was significantly different between the OBS (57%) and END (80%) groups (p = 0.031). In patients with sonographic DOI <4.0 mm, the 5-year DSS rates were 79 and 89% in OBS and END groups, respectively, and were not significantly different. However, in patients with sonographic DOI ≥4.0 mm, the 5-year DSS rate was significantly different between the OBS (67%) and END (86%) groups (p = 0.033).
CONCLUSIONS: Sonographic DOI was notably correlated with pathologic DOI. Moreover, there was a significant survival difference between the OBS and END groups in cT1N0 tongue SCC patients with sonographic DOI ≥4.0 mm but not in those with sonographic DOI <4.0 mm. Our study provides a useful method to aid decision-making in the clinical setting for this patient group.
摘要：
目的：比较cT1N0舌鳞状细胞癌（SCC）患者接受超声浸润深度（DOI）分层的不同颈部管理策略的肿瘤学结果。
方法：对纳入的患者进行回顾性研究，分为两组：不雅察(OBS)和择期颈清扫术(END)。比较区域控制率（RC）和疾病特异性生存率（DSS）并通过超声DOI进行分层。
结果：平均超声和病理DOI为3.8和3.7mm，分别；两个DOIs显著相关(Spearman相关系数0.974。p<0.001)。在超声DOI<4.0mm的患者中，OBS和END组的5年RC率为73%和89%，分别,并且没有显着差异。然而,在超声DOI≥4.0mm的患者中，OBS(57%)和END(80%)组的5年RC率存在显著差异(p=0.031).在超声DOI<4.0mm的患者中，OBS和END组的5年DSS率为79%和89%，分别,并且没有显着差异。然而,在超声DOI≥4.0mm的患者中，OBS(67%)和END(86%)组的5年DSS发生率有显著差异(p=0.033).
结论：超声DOI与病理性DOI显著相关。此外，在超声DOI≥4.0mm的cT1N0舌SCC患者中，OBS组和END组之间的生存差异显着，而在超声DOI<4.0mm的患者中没有差异。我们的研究提供了一种有用的方法来帮助该患者组的临床决策。
方法：对纳入的患者进行回顾性研究，分为两组：不雅察(OBS)和择期颈清扫术(END)。比较区域控制率（RC）和疾病特异性生存率（DSS）并通过超声DOI进行分层。
结果：平均超声和病理DOI为3.8和3.7mm，分别；两个DOIs显著相关(Spearman相关系数0.974。p<0.001)。在超声DOI<4.0mm的患者中，OBS和END组的5年RC率为73%和89%，分别,并且没有显着差异。然而,在超声DOI≥4.0mm的患者中，OBS(57%)和END(80%)组的5年RC率存在显著差异(p=0.031).在超声DOI<4.0mm的患者中，OBS和END组的5年DSS率为79%和89%，分别,并且没有显着差异。然而,在超声DOI≥4.0mm的患者中，OBS(67%)和END(86%)组的5年DSS发生率有显著差异(p=0.033).
结论：超声DOI与病理性DOI显著相关。此外，在超声DOI≥4.0mm的cT1N0舌SCC患者中，OBS组和END组之间的生存差异显着，而在超声DOI<4.0mm的患者中没有差异。我们的研究提供了一种有用的方法来帮助该患者组的临床决策。
