Abstract：
This study aimed to explore the characteristics of laryngopharyngeal reflux (LPR) and the association between LPR and allergic rhinitis (AR).
In this prospective case-control study, a total of 102 patients with suspected LPR who visited the Department of Otolaryngology Head and Neck Surgery, Heping Hospital Affiliated to Changzhi Medical College, between June 2019 and June 2021 were consecutively included. They were divided into the LPR-positive group and the LPR-negative group according to 24-h Dx-pH monitoring. The influencing factors of LPR, including the scores for AR (SFAR) and AR prevalence, were compared between the two groups.
The total SFAR and scores in items 1, 3, 4, and 5 of the LPR-positive group were significantly higher than those of the LPR-negative group (p < 0.05). The prevalence of AR in the LPR-positive group was 60%, which was significantly higher than that in the LPR-negative group (36.54%) (p < 0.05). After excluding confounding factors, AR was positively correlated with the incidence of LPR, and the incidence of LPR with AR was 2.372 times that of non-AR. Receiver operating characteristic curve results show that AR has the highest predictive value for LPR, and the area of AR under the curve is was 0.617.
The SFAR and incidence of AR are high in patients with positive LPR, and AR may be a risk factor for LPR. The results of this study may deepen our understanding of the occurrence of LPR.
In this prospective case-control study, a total of 102 patients with suspected LPR who visited the Department of Otolaryngology Head and Neck Surgery, Heping Hospital Affiliated to Changzhi Medical College, between June 2019 and June 2021 were consecutively included. They were divided into the LPR-positive group and the LPR-negative group according to 24-h Dx-pH monitoring. The influencing factors of LPR, including the scores for AR (SFAR) and AR prevalence, were compared between the two groups.
The total SFAR and scores in items 1, 3, 4, and 5 of the LPR-positive group were significantly higher than those of the LPR-negative group (p < 0.05). The prevalence of AR in the LPR-positive group was 60%, which was significantly higher than that in the LPR-negative group (36.54%) (p < 0.05). After excluding confounding factors, AR was positively correlated with the incidence of LPR, and the incidence of LPR with AR was 2.372 times that of non-AR. Receiver operating characteristic curve results show that AR has the highest predictive value for LPR, and the area of AR under the curve is was 0.617.
The SFAR and incidence of AR are high in patients with positive LPR, and AR may be a risk factor for LPR. The results of this study may deepen our understanding of the occurrence of LPR.
摘要：
本研究旨在探讨咽喉反流(LPR)的特点及其与变应性鼻炎(AR)的关系。
在这项前瞻性病例对照研究中，共有102名疑似LPR患者就诊于耳鼻咽喉头颈外科，长治医学院附属和平医院,2019年6月至2021年6月间连续纳入。根据24小时Dx-pH监测将其分为LPR阳性组和LPR阴性组。LPR的影响因素,包括AR(SFAR)和AR患病率的分数，对两组进行比较。
LPR阳性组的总SFAR和第1、3、4和5项评分均明显高于LPR阴性组（p<0.05）。LPR阳性组的AR患病率为60%,显著高于LPR阴性组(36.54%)(p<0.05)。排除混杂因素后，AR与LPR的发生率呈正相关,有AR的LPR发生率是无AR的2.372倍。接收机工作特性曲线结果表明，AR对LPR的预测价值最高，曲线下AR面积为0.617。
LPR阳性患者的SFAR和AR发生率较高，而AR可能是LPR的风险因素。本研究结果可能加深我们对LPR发生的认识。
在这项前瞻性病例对照研究中，共有102名疑似LPR患者就诊于耳鼻咽喉头颈外科，长治医学院附属和平医院,2019年6月至2021年6月间连续纳入。根据24小时Dx-pH监测将其分为LPR阳性组和LPR阴性组。LPR的影响因素,包括AR(SFAR)和AR患病率的分数，对两组进行比较。
LPR阳性组的总SFAR和第1、3、4和5项评分均明显高于LPR阴性组（p<0.05）。LPR阳性组的AR患病率为60%,显著高于LPR阴性组(36.54%)(p<0.05)。排除混杂因素后，AR与LPR的发生率呈正相关,有AR的LPR发生率是无AR的2.372倍。接收机工作特性曲线结果表明，AR对LPR的预测价值最高，曲线下AR面积为0.617。
LPR阳性患者的SFAR和AR发生率较高，而AR可能是LPR的风险因素。本研究结果可能加深我们对LPR发生的认识。
