Abstract：
OBJECTIVE: To evaluate the effects of minimally invasive micro-osteoperforations (MOPs) on orthodontic tooth movement and pain.
METHODS: Prospective, split-mouth, randomized controlled trial.
METHODS: Single-centre, university hospital.
METHODS: Twenty subjects requiring maxillary first premolar extractions were included. Right and left sides of the maxilla were randomly allocated into experimental and controls. Space closure was initiated following alignment on 0.20″ stainless steel archwires, using 150 g force, applied by coil springs on power arms. Nance-TPA was used for anchorage. On the experimental side, two 5 mm deep MOPs in vertical alignment on distal aspect of the maxillary canine mid-root region were performed prior to space closure.
RESULTS: The primary outcome was the amount of tooth movement during space closure, measured every 4 weeks for 12 weeks (T1, T2, and T3). Secondary outcome was the pain levels related to MOP, measured using Visual Analogue Scale (VAS) questionnaires. Significance was set at P < 0.01.
METHODS: Randomization was generated using a randomization table, and allocation was concealed in sequentially numbered, opaque, sealed envelopes.
METHODS: Blinding was not possible during the experiment but assessor was blinded during outcome assessment.
RESULTS: All subjects completed the study, with tooth movement measurements available for all 20 patients for T0-T2. In three patients, space was closed on one side at T2. The average tooth movement between sides at three intervals (T0-T1, T1-T2, and T2-T3) were not significantly different. Overall difference following 12 weeks (T0-T3) was 0.69 mm higher on the experimental side (P < 0.001). No harms were observed.
CONCLUSIONS: Short-term study, cast measurements done with digital callipers.
CONCLUSIONS: This 12-week randomized split-mouth controlled clinical trial showed two MOPs that are 5 mm deep, applied once prior to space closure, did not create clinically significant increase in maxillary premolar space closure.
METHODS: The protocol was not published before trial commencement.
BACKGROUND: Trial was not registered.
BACKGROUND: The Australian Society of Orthodontists Foundation for Research and Education.
METHODS: Prospective, split-mouth, randomized controlled trial.
METHODS: Single-centre, university hospital.
METHODS: Twenty subjects requiring maxillary first premolar extractions were included. Right and left sides of the maxilla were randomly allocated into experimental and controls. Space closure was initiated following alignment on 0.20″ stainless steel archwires, using 150 g force, applied by coil springs on power arms. Nance-TPA was used for anchorage. On the experimental side, two 5 mm deep MOPs in vertical alignment on distal aspect of the maxillary canine mid-root region were performed prior to space closure.
RESULTS: The primary outcome was the amount of tooth movement during space closure, measured every 4 weeks for 12 weeks (T1, T2, and T3). Secondary outcome was the pain levels related to MOP, measured using Visual Analogue Scale (VAS) questionnaires. Significance was set at P < 0.01.
METHODS: Randomization was generated using a randomization table, and allocation was concealed in sequentially numbered, opaque, sealed envelopes.
METHODS: Blinding was not possible during the experiment but assessor was blinded during outcome assessment.
RESULTS: All subjects completed the study, with tooth movement measurements available for all 20 patients for T0-T2. In three patients, space was closed on one side at T2. The average tooth movement between sides at three intervals (T0-T1, T1-T2, and T2-T3) were not significantly different. Overall difference following 12 weeks (T0-T3) was 0.69 mm higher on the experimental side (P < 0.001). No harms were observed.
CONCLUSIONS: Short-term study, cast measurements done with digital callipers.
CONCLUSIONS: This 12-week randomized split-mouth controlled clinical trial showed two MOPs that are 5 mm deep, applied once prior to space closure, did not create clinically significant increase in maxillary premolar space closure.
METHODS: The protocol was not published before trial commencement.
BACKGROUND: Trial was not registered.
BACKGROUND: The Australian Society of Orthodontists Foundation for Research and Education.
摘要：
目的：评价微创微骨术（MOPs）对正畸牙齿移动和疼痛的影响。
方法：前瞻性，裂口,随机对照试验。
方法：单中心，大学医院。
方法：包括20名需要上颌第一前磨牙拔除的受试者。上颌骨的右侧和左侧被随机分配到实验和对照中。在0.20英寸不锈钢弓丝上对齐后开始空间闭合，使用150克的力，由螺旋弹簧施加在动力臂。Nance-TPA用于锚固。在实验方面，在闭合空间之前，在上颌犬齿中根区域的远端进行了两个5mm深的MOP垂直对齐。
结果：主要结果是空间闭合过程中牙齿的移动量，每4周测量12周（T1，T2和T3）。次要结果是与MOP相关的疼痛水平，使用视觉模拟量表(VAS)问卷测量。显著性设定为P<0.01。
方法：使用随机化表生成随机化，分配被隐藏在顺序编号中，不透明,密封的信封。
方法：在实验期间不可能进行致盲，但在结果评估期间，评估者是致盲的。
结果：所有受试者完成研究，所有20例T0-T2患者均可进行牙齿移动测量。在三个病人中，空间在T2的一侧是封闭的。三个间隔（T0-T1，T1-T2和T2-T3）的两侧之间的平均牙齿移动没有显着差异。12周后（T0-T3）的总差异在实验侧高出0.69mm（P<0.001）。没有观察到危害。
结论：短期研究，用数字卡尺铸造测量。
结论：这项为期12周的随机分口对照临床试验显示了两个5毫米深的MOP，在空间闭合之前应用一次，上颌前磨牙间隙闭合没有产生临床上的显着增加。
方法：试验开始前没有公布方案。
背景：试验未注册。
背景：澳大利亚牙齿矫正医师协会研究与教育基金会。
方法：前瞻性，裂口,随机对照试验。
方法：单中心，大学医院。
方法：包括20名需要上颌第一前磨牙拔除的受试者。上颌骨的右侧和左侧被随机分配到实验和对照中。在0.20英寸不锈钢弓丝上对齐后开始空间闭合，使用150克的力，由螺旋弹簧施加在动力臂。Nance-TPA用于锚固。在实验方面，在闭合空间之前，在上颌犬齿中根区域的远端进行了两个5mm深的MOP垂直对齐。
结果：主要结果是空间闭合过程中牙齿的移动量，每4周测量12周（T1，T2和T3）。次要结果是与MOP相关的疼痛水平，使用视觉模拟量表(VAS)问卷测量。显著性设定为P<0.01。
方法：使用随机化表生成随机化，分配被隐藏在顺序编号中，不透明,密封的信封。
方法：在实验期间不可能进行致盲，但在结果评估期间，评估者是致盲的。
结果：所有受试者完成研究，所有20例T0-T2患者均可进行牙齿移动测量。在三个病人中，空间在T2的一侧是封闭的。三个间隔（T0-T1，T1-T2和T2-T3）的两侧之间的平均牙齿移动没有显着差异。12周后（T0-T3）的总差异在实验侧高出0.69mm（P<0.001）。没有观察到危害。
结论：短期研究，用数字卡尺铸造测量。
结论：这项为期12周的随机分口对照临床试验显示了两个5毫米深的MOP，在空间闭合之前应用一次，上颌前磨牙间隙闭合没有产生临床上的显着增加。
方法：试验开始前没有公布方案。
背景：试验未注册。
背景：澳大利亚牙齿矫正医师协会研究与教育基金会。
