Abstract：
Human pegivirus (HPgV-1), previously known as GB virus C (GBV-C) or hepatitis G virus (HGV), is a single-stranded positive RNA virus belonging to the genus Pegivirus of the Flaviviridae family. It is transmitted by percutaneous injuries (PIs), contaminated blood and/or blood products, sexual contact, and vertical mother-to-child transmission. It is widely prevalent in general population, especially in high-risk groups. HPgV-1 viremia is typically cleared within the first 1-2 years of infection in most healthy individuals, but may persist for longer periods of time in immunocompromised individuals and/or those co-infected by other viruses. A large body of evidences indicate that HPgV-1 persistent infection has a beneficial clinical effect on many infectious diseases, such as acquired immunodeficiency syndrome (AIDS) and hepatitis C. The beneficial effects seem to be related to a significant reduction of immune activation, and/or the inhabitation of co-infected viruses (e.g. HIV-1). HPgV-1 has a broad cellular tropism for lymphoid and myeloid cells, and preferentially replicates in bone marrow and spleen without cytopathic effect, implying a therapeutic potential. The paper aims to summarize the natural history, prevalence and distribution characteristics, and pathogenesis of HPgV-1, and discuss its association with other human viral diseases, and potential use in therapy as a biovaccine or viral vector.
摘要：
人类pegivirus(HPgV-1),以前称为GB病毒C（GBV-C）或庚型肝炎病毒（HGV），是属于黄病毒科的Pegivirus属的单链正RNA病毒。它通过经皮损伤（PI）传播，受污染的血液和/或血液制品，性接触,和垂直母婴传播。它在普通人群中广泛流行，尤其是高危人群。在大多数健康个体中，HPgV-1病毒血症通常在感染的前1-2年内被清除。但在免疫受损个体和/或被其他病毒共同感染的个体中可能持续更长的时间。大量证据表明，HPgV-1持续感染对许多感染性疾病具有有益的临床作用，如获得性免疫缺陷综合征（AIDS）和丙型肝炎。和/或共同感染的病毒(例如HIV-1)的居住。HPgV-1对淋巴和骨髓细胞具有广泛的细胞嗜性，并优先在骨髓和脾脏中复制，而没有细胞病变作用，暗示治疗潜力。本文旨在总结自然史，流行和分布特征，和HPgV-1的发病机制，并讨论其与其他人类病毒性疾病的关系，以及作为生物疫苗或病毒载体在治疗中的潜在用途。
