Abstract：
IgE multiple myeloma is a rare subtype of myeloma, accounting for <0.1% of all myeloma cases. Difficulties in diagnosing and monitoring this rare myeloma type are recognized, including the need of heightened awareness for initial diagnosis, performing a reflex immunofixation test using an anti-IgE antisera, and recognizing the possibility of the prozone phenomenon. Here, we report a rare case of IgE multiple myeloma with the prozone phenomenon. This case was characterized by a paradoxical increase in IgE levels with a progressive increase in the dilution factor. Moreover, serial monitoring of IgE levels correlated with the trend in the serum free light chain ratio, especially when the monoclonal protein was no longer detectable. This case highlights the need for laboratory professionals to be vigilant about the occurrence of the prozone phenomenon in IgE multiple myeloma.
摘要：
IgE多发性骨髓瘤是一种罕见的骨髓瘤亚型，占所有骨髓瘤病例的0.1%。认识到诊断和监测这种罕见的骨髓瘤类型的困难，包括需要提高初始诊断的意识，使用抗IgE抗血清进行反射性免疫固定试验，并认识到前区现象的可能性。这里,我们报道了一例罕见的IgE多发性骨髓瘤伴前区现象。这种情况的特征是IgE水平矛盾地增加，稀释因子逐渐增加。此外，IgE水平的系列监测与血清游离轻链比率的趋势相关，特别是当单克隆蛋白不再被检测到时。此病例凸显了实验室专业人员对IgE多发性骨髓瘤中前区现象的发生保持警惕的必要性。
