PDF(Pubmed)
Abstract：
BACKGROUND: Ossification of the posterior longitudinal ligament (OPLL) is radiographically detectable in 3-6% of Asian individuals, although not all detectable OPLL cases lead to myelopathy. To date, it is unknown how many patients suffer from neurological symptoms due to OPLL. The purpose of this study was to investigate the epidemiology of symptomatic OPLL using Japan\'s national registry database.
METHODS: We examined the registry data of patients with OPLL who held a certificate of medical subsidy from the Japanese Ministry of Health, Labor and Welfare. The study period was from January 1, 2011 to December 31, 2012.
RESULTS: Registry data revealed that the incidence and the period prevalence of symptomatic OPLL were 0.005% (5 per 100,000 population) and 0.027% (27 per 100,000 population), respectively. OPLL occurred twice as often in men as in women. The peak age for onset of symptoms was 60-69 years. The mean Japanese Orthopedic Association (JOA) score was 9 points. Ninety percent of OPLL patients underwent surgery, and 90% of these surgeries were performed with a posterior approach. The most common indication for surgery was a JOA score of 11 points.
CONCLUSIONS: According to registry data, the prevalence of symptomatic OPLL was less than one-hundredth of that of radiographically detected OPLL. This indicates that most cases of radiographically detectable OPLL may be asymptomatic.
METHODS: We examined the registry data of patients with OPLL who held a certificate of medical subsidy from the Japanese Ministry of Health, Labor and Welfare. The study period was from January 1, 2011 to December 31, 2012.
RESULTS: Registry data revealed that the incidence and the period prevalence of symptomatic OPLL were 0.005% (5 per 100,000 population) and 0.027% (27 per 100,000 population), respectively. OPLL occurred twice as often in men as in women. The peak age for onset of symptoms was 60-69 years. The mean Japanese Orthopedic Association (JOA) score was 9 points. Ninety percent of OPLL patients underwent surgery, and 90% of these surgeries were performed with a posterior approach. The most common indication for surgery was a JOA score of 11 points.
CONCLUSIONS: According to registry data, the prevalence of symptomatic OPLL was less than one-hundredth of that of radiographically detected OPLL. This indicates that most cases of radiographically detectable OPLL may be asymptomatic.
摘要：
背景：在3-6％的亚洲人中可以通过影像学检查检测到后纵韧带（OPLL）骨化，尽管并非所有可检测到的OPLL病例都会导致脊髓病。迄今为止,目前尚不清楚有多少患者因OPLL而出现神经系统症状。这项研究的目的是使用日本国家注册数据库调查有症状的OPLL的流行病学。
方法：我们检查了持有日本卫生部医疗补助证明的OPLL患者的注册数据，劳动与福利。研究期间为2011年1月1日至2012年12月31日。
结果：注册数据显示，有症状的OPLL的发病率和经期患病率分别为0.005％（5/100,000人口）和0.027％（27/100,000人口）。分别。OPLL在男性中的发生率是女性的两倍。症状发作的高峰年龄为60-69岁。日本骨科协会（JOA）平均得分为9分。90%的OPLL患者接受了手术，这些手术中有90％采用后路手术。最常见的手术指征是JOA得分为11分。
结论：根据注册表数据，有症状的OPLL的患病率低于影像学检查检测到的OPLL的百分之一.这表明大多数射线照相可检测的OPLL病例可能无症状。
方法：我们检查了持有日本卫生部医疗补助证明的OPLL患者的注册数据，劳动与福利。研究期间为2011年1月1日至2012年12月31日。
结果：注册数据显示，有症状的OPLL的发病率和经期患病率分别为0.005％（5/100,000人口）和0.027％（27/100,000人口）。分别。OPLL在男性中的发生率是女性的两倍。症状发作的高峰年龄为60-69岁。日本骨科协会（JOA）平均得分为9分。90%的OPLL患者接受了手术，这些手术中有90％采用后路手术。最常见的手术指征是JOA得分为11分。
结论：根据注册表数据，有症状的OPLL的患病率低于影像学检查检测到的OPLL的百分之一.这表明大多数射线照相可检测的OPLL病例可能无症状。
