PDF(Pubmed)
Abstract：
Lipid rafts, also known as microdomains, are important components of cell membranes and are enriched in cholesterol, glycophospholipids and receptors. They are involved in various essential cellular processes, including endocytosis, exocytosis and cellular signaling. Receptors are concentrated at lipid rafts, through which cellular signaling can be transmitted. Pathogens exploit these signaling mechanisms to enter cells, proliferate and egress. However, lipid rafts also play an important role in initiating antimicrobial responses by sensing pathogens via clustered pathogen-sensing receptors and triggering downstream signaling events such as programmed cell death or cytokine production for pathogen clearance. In this review, we discuss how both host and pathogens use lipid rafts and associated proteins in an arms race to survive. Special attention is given to the involvement of the major vault protein, the main constituent of a ribonucleoprotein complex, which is enriched in lipid rafts upon infection with vaccinia virus.
摘要：
脂筏,也被称为微域，是细胞膜的重要组成部分，富含胆固醇，糖磷脂和受体。它们参与各种基本的细胞过程，包括内吞作用,胞吐和细胞信号。受体集中在脂筏上，通过它可以传输蜂窝信令。病原体利用这些信号机制进入细胞，扩散和出口。然而,脂筏通过聚集的病原体感知受体感知病原体并触发下游信号事件，例如程序性细胞死亡或细胞因子产生以清除病原体，在启动抗微生物反应中也起重要作用。在这次审查中,我们讨论了宿主和病原体如何在军备竞赛中利用脂筏和相关蛋白生存。特别注意主要金库蛋白的参与，核糖核蛋白复合物的主要成分，牛痘病毒感染后富含脂筏。
