干扰素 α 11 , 而不是干扰素 β 的免疫治疗 ,控制持续性逆转录病毒感染。
关键词: Friend retrovirus Type I IFNs cytotoxic CD8+ T cells immunotherapy persistent infection retroviral infection
Mesh : Animals Antiviral Agents / pharmacology Biomarkers Cell Line Cytotoxicity, Immunologic / drug effects Disease Management Disease Models, Animal Female Friend murine leukemia virus / physiology Host-Pathogen Interactions / immunology Immunologic Factors / pharmacology Interferon Type I / pharmacology Interferon-alpha / pharmacology Interferon-beta / pharmacology Leukemia Virus, Murine / physiology Lymphocytes / immunology metabolism Mice Retroviridae Infections / drug therapy immunology virology Treatment Outcome Viral Load / drug effects Virus Replication / drug effects
来 源:
DOI:10.3389/fimmu.2021.809774
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