PDF(Pubmed)
Abstract：
Radiation therapy is the treatment of choice for cats with sinonasal carcinomas. Different protocols have been described in the literature, though a clear consensus regarding the optimal protocol is lacking. The aim of the study was to describe the tolerability, efficacy and outcome of cats treated with a cyclical hypofractionated protocol.
Cats with histologically diagnosed sinonasal carcinomas in a single institution were retrospectively included. All patients were treated with a cyclical hypofractionated protocol (\'QUAD shot\' regime). Cats were treated with 4 Gray (Gy) delivered in four fractions within 48 h, with a minimum of 6 h between two treatments, and repeated every 3-4 weeks for a total dose of 48 Gy in three cycles.
Seven cats met the inclusion criteria. Nasal discharge and sneezing were the most common presenting complaints. All cats presented with advanced stage of disease with CT examination (three with modified Adams stage 3 and four with stage 4). Clinical improvement was seen in six cats. Five cats had a follow-up CT; one had a complete response, two had partial responses, one had stable disease and one had progressive disease. Two cats were still alive at the time of writing while four were euthanased owing to tumour-related causes. The median overall survival time was 460 days. The 1-year survival time was 80% and the 2-year survival time was 0%. Severe acute or late toxicity was not reported.
This is the first report of a cyclical hypofractionated protocol in the veterinary literature that can provide prolonged survival in cats with advanced stage sinonasal carcinoma. Its use should be considered in patients when prolonged hospitalisation can be detrimental to quality of life, while still delivering a therapeutic total dose of radiation therapy.
Cats with histologically diagnosed sinonasal carcinomas in a single institution were retrospectively included. All patients were treated with a cyclical hypofractionated protocol (\'QUAD shot\' regime). Cats were treated with 4 Gray (Gy) delivered in four fractions within 48 h, with a minimum of 6 h between two treatments, and repeated every 3-4 weeks for a total dose of 48 Gy in three cycles.
Seven cats met the inclusion criteria. Nasal discharge and sneezing were the most common presenting complaints. All cats presented with advanced stage of disease with CT examination (three with modified Adams stage 3 and four with stage 4). Clinical improvement was seen in six cats. Five cats had a follow-up CT; one had a complete response, two had partial responses, one had stable disease and one had progressive disease. Two cats were still alive at the time of writing while four were euthanased owing to tumour-related causes. The median overall survival time was 460 days. The 1-year survival time was 80% and the 2-year survival time was 0%. Severe acute or late toxicity was not reported.
This is the first report of a cyclical hypofractionated protocol in the veterinary literature that can provide prolonged survival in cats with advanced stage sinonasal carcinoma. Its use should be considered in patients when prolonged hospitalisation can be detrimental to quality of life, while still delivering a therapeutic total dose of radiation therapy.
摘要：
目的：放射治疗是治疗猫鼻窦癌的首选方法。文献中描述了不同的协议，尽管缺乏关于最佳协议的明确共识。这项研究的目的是描述耐受性，用周期性低分割方案治疗的猫的疗效和结果。
方法：回顾性纳入了一个机构中组织学诊断为鼻窦癌的猫。所有患者均采用周期性低分割方案（“QUAD注射”方案）进行治疗。在48小时内，猫用4Gray（Gy）分四个部分进行处理，两次治疗之间至少6小时，每3-4周重复一次，共3个周期，总剂量为48Gy。
结果：7只猫符合纳入标准。流鼻涕和打喷嚏是最常见的投诉。通过CT检查，所有猫都表现出疾病的晚期（三只改良的Adams阶段3和四只阶段4）。在六只猫中观察到临床改善。五只猫进行了CT随访；一只有完全反应，两个有部分反应，其中一人病情稳定，一人病情进展。在撰写本文时，两只猫仍然活着，而由于肿瘤相关原因，四只猫被安乐死。中位总生存时间为460天。1年生存时间为80％，2年生存时间为0％。未报告严重急性或晚期毒性。
结论：这是兽医文献中关于周期性大分割方案的首次报道，该方案可以延长晚期鼻窦癌的猫的生存期。当长期住院可能不利于生活质量时，应考虑在患者中使用它，同时仍提供治疗总剂量的放射治疗。
方法：回顾性纳入了一个机构中组织学诊断为鼻窦癌的猫。所有患者均采用周期性低分割方案（“QUAD注射”方案）进行治疗。在48小时内，猫用4Gray（Gy）分四个部分进行处理，两次治疗之间至少6小时，每3-4周重复一次，共3个周期，总剂量为48Gy。
结果：7只猫符合纳入标准。流鼻涕和打喷嚏是最常见的投诉。通过CT检查，所有猫都表现出疾病的晚期（三只改良的Adams阶段3和四只阶段4）。在六只猫中观察到临床改善。五只猫进行了CT随访；一只有完全反应，两个有部分反应，其中一人病情稳定，一人病情进展。在撰写本文时，两只猫仍然活着，而由于肿瘤相关原因，四只猫被安乐死。中位总生存时间为460天。1年生存时间为80％，2年生存时间为0％。未报告严重急性或晚期毒性。
结论：这是兽医文献中关于周期性大分割方案的首次报道，该方案可以延长晚期鼻窦癌的猫的生存期。当长期住院可能不利于生活质量时，应考虑在患者中使用它，同时仍提供治疗总剂量的放射治疗。
