Abstract：
Burning mouth syndrome is a chronic condition, which is characterised by a burning sensation or pain in the mucosa of the oral cavity. Treatment options include antidepressants, antipsychotics, anticonvulsants, analgesics, hormone replacement therapies and more recently photobiomodulation. This study aims to perform a systematic review with meta-analysis in order to determine the effect of photobiomodulation on pain relief and the oral health-related quality of life associated with this condition. A bibliographical search of the Pubmed, Embase, Web of Science and Scopus databases was conducted. Only randomised clinical trials were included. Pain and quality of life were calculated as mean difference and pooled at different treatment points (baseline = T0 and final time point = Tf) and laser modality. From a total of 103 records, 7 articles were retrieved for inclusion. PBM group had a greater decrease in pain than control group at Tf with a mean difference = - 2.536 (IC 95% - 3.662 to - 1.410; I2 = 85.33%, p < 0.001). An improvement in oral health-related quality of life was observed in both groups, although this was more significant in the photobiomodulation group mean difference = - 5.148 (IC 95% - 8.576 to - 1.719; I2 = 84.91%, p = 0.003). For the red laser, a greater improvement than infrared was observed, in pain, mean difference = - 2.498 (IC 95% - 3.942 to - 1.053; I2 = 79.93%, p < 0.001), and in quality of life, mean difference = - 8.144 (IC 95% - 12.082 to - 4.206; I2 = 64.22%, p = 0.027). Photobiomodulation, in particular, red laser protocols, resulted in improvement in pain and in quality of life of burning mouth syndrome patients.
摘要：
灼口综合症是一种慢性疾病，其特征在于口腔粘膜中的灼烧感或疼痛。治疗选择包括抗抑郁药,抗精神病药,抗惊厥药,镇痛药,激素替代疗法和最近的光生物调节。这项研究旨在通过荟萃分析进行系统评价，以确定光生物调节对疼痛缓解的影响以及与这种情况相关的口腔健康相关的生活质量。Pubmed的书目搜索，Embase,进行了WebofScience和Scopus数据库。仅包括随机临床试验。疼痛和生活质量计算为平均差，并在不同治疗点（基线=T0，最终时间点=Tf）和激光模式下汇总。在总共103条记录中，已检索到7篇文章以供收录。在Tf时，PBM组比对照组的疼痛减少更大，平均差异=-2.536（IC95％-3.662至-1.410；I2=85.33％，p<0.001)。两组均观察到口腔健康相关生活质量的改善，尽管这在光生物调节组中更为显着，但平均差=-5.148（IC95％-8.576至-1.719；I2=84.91％，p=0.003)。对于红色激光，观察到比红外线更大的改善，在痛苦中，平均差=-2.498(IC95%-3.942至-1.053；I2=79.93%，p<0.001)，在生活质量方面，平均差=-8.144(IC95%-12.082至-4.206；I2=64.22%，p=0.027)。光生物调节,特别是,红色激光协议，改善灼口综合征患者的疼痛和生活质量。
