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Abstract：
BACKGROUND: To review the evidence on the oral health-related quality of life (OHRQoL) of head and neck cancer survivors after they have been treated with prosthetic rehabilitation.
METHODS: Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) were utilized as the framework in designing, implementing and reporting the current review. Search of literature was done electronically using Medline, Embase, and Cochrane databases. Intervention component of the patient, intervention, comparison, outcome (PICO) for the current review was the prosthetic rehabilitation performed on the surgically treated head and neck cancer patients (participants); and outcome was the OHRQoL. Methodological index for non-randomized studies was the assessment tool utilized to report on the quality of the included studies.
RESULTS: The initial search had identified 799 records and the final level of screening included eight articles. Six studies were experimental in design and two were cross-sectional. Cumulative sample of the head and neck cancer cases from the selected studies was 354, with 35.9 (14.9) and 72.4 (8.7) years as the highest and lowest mean age recorded from the included studies. More male cases (69.5%) were reported than female cases (30.5%) and squamous cell carcinoma was the most commonly diagnosed malignancy. Maxillary reconstruction and implant supported prosthesis were the choice of treatment for most of the cases. Different versions of oral health impact profile (OHIP) constructs were preferred by six studies. While, one study utilized University of Washington quality of life questionnaire and the other utilized European Organization for Research and Treatment of Cancer\'s Quality of Life Questionnaire. Arguably, three studies had compared the OHRQoL scores of head and neck cancer patients with healthy counterparts through a follow-up period ranging from 1 to 2 years.
CONCLUSIONS: The included studies did not provide substantial evidence to demonstrate the improvement in OHRQoL of head and neck cancer patients after prosthetic rehabilitation. More prospective studies are needed with representative sample, robust methodology and a longer follow-up period. The current study provides a direction to the clinical decision-making process and the epidemiological research to enhance the patients and public health-related outcomes.
METHODS: Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) were utilized as the framework in designing, implementing and reporting the current review. Search of literature was done electronically using Medline, Embase, and Cochrane databases. Intervention component of the patient, intervention, comparison, outcome (PICO) for the current review was the prosthetic rehabilitation performed on the surgically treated head and neck cancer patients (participants); and outcome was the OHRQoL. Methodological index for non-randomized studies was the assessment tool utilized to report on the quality of the included studies.
RESULTS: The initial search had identified 799 records and the final level of screening included eight articles. Six studies were experimental in design and two were cross-sectional. Cumulative sample of the head and neck cancer cases from the selected studies was 354, with 35.9 (14.9) and 72.4 (8.7) years as the highest and lowest mean age recorded from the included studies. More male cases (69.5%) were reported than female cases (30.5%) and squamous cell carcinoma was the most commonly diagnosed malignancy. Maxillary reconstruction and implant supported prosthesis were the choice of treatment for most of the cases. Different versions of oral health impact profile (OHIP) constructs were preferred by six studies. While, one study utilized University of Washington quality of life questionnaire and the other utilized European Organization for Research and Treatment of Cancer\'s Quality of Life Questionnaire. Arguably, three studies had compared the OHRQoL scores of head and neck cancer patients with healthy counterparts through a follow-up period ranging from 1 to 2 years.
CONCLUSIONS: The included studies did not provide substantial evidence to demonstrate the improvement in OHRQoL of head and neck cancer patients after prosthetic rehabilitation. More prospective studies are needed with representative sample, robust methodology and a longer follow-up period. The current study provides a direction to the clinical decision-making process and the epidemiological research to enhance the patients and public health-related outcomes.
摘要：
背景：回顾头颈部癌症幸存者在接受假肢康复治疗后口腔健康相关生活质量（OHRQoL）的证据。
方法：系统评价和荟萃分析（PRISMA）的首选报告项目被用作设计的框架，实施和报告当前的审查。文献搜索是使用Medline以电子方式完成的，Embase,和Cochrane数据库。患者的干预部分，干预，比较,本综述的结局(PICO)是对手术治疗的头颈部癌症患者(参与者)进行的假肢康复;结局是OHRQoL.非随机研究的方法学指标是用于报告纳入研究质量的评估工具。
结果：最初的搜索已经确定了799条记录，最终的筛选水平包括8篇文章。六项研究是实验设计，两项是横断面研究。来自所选研究的头颈癌病例的累积样本为354，其中35.9（14.9）和72.4（8.7）岁是所包括研究记录的最高和最低平均年龄。报告的男性病例（69.5％）多于女性病例（30.5％），鳞状细胞癌是最常见的恶性肿瘤。上颌骨重建和植入物支持的假体是大多数病例的治疗选择。六项研究首选不同版本的口腔健康影响概况(OHIP)构建体。同时,一项研究利用华盛顿大学的生活质量问卷，另一项利用欧洲癌症研究和治疗组织的生活质量问卷。可以说,在1~2年的随访期内,有3项研究比较了头颈癌患者与健康者的OHRQoL评分.
结论：纳入的研究没有提供大量证据证明头颈部癌症患者在修复后OHRQoL的改善。需要更多具有代表性样本的前瞻性研究，稳健的方法和更长的随访期。当前的研究为临床决策过程和流行病学研究提供了方向，以增强患者和公共卫生相关的结果。
方法：系统评价和荟萃分析（PRISMA）的首选报告项目被用作设计的框架，实施和报告当前的审查。文献搜索是使用Medline以电子方式完成的，Embase,和Cochrane数据库。患者的干预部分，干预，比较,本综述的结局(PICO)是对手术治疗的头颈部癌症患者(参与者)进行的假肢康复;结局是OHRQoL.非随机研究的方法学指标是用于报告纳入研究质量的评估工具。
结果：最初的搜索已经确定了799条记录，最终的筛选水平包括8篇文章。六项研究是实验设计，两项是横断面研究。来自所选研究的头颈癌病例的累积样本为354，其中35.9（14.9）和72.4（8.7）岁是所包括研究记录的最高和最低平均年龄。报告的男性病例（69.5％）多于女性病例（30.5％），鳞状细胞癌是最常见的恶性肿瘤。上颌骨重建和植入物支持的假体是大多数病例的治疗选择。六项研究首选不同版本的口腔健康影响概况(OHIP)构建体。同时,一项研究利用华盛顿大学的生活质量问卷，另一项利用欧洲癌症研究和治疗组织的生活质量问卷。可以说,在1~2年的随访期内,有3项研究比较了头颈癌患者与健康者的OHRQoL评分.
结论：纳入的研究没有提供大量证据证明头颈部癌症患者在修复后OHRQoL的改善。需要更多具有代表性样本的前瞻性研究，稳健的方法和更长的随访期。当前的研究为临床决策过程和流行病学研究提供了方向，以增强患者和公共卫生相关的结果。
