PDF(Pubmed)
Abstract：
Sjogren\'s syndrome (SS) is a systemic autoimmune disease marked by lymphocyte infiltration of the exocrine glands and a variety of systemic symptoms. The wide range of prevalence reported in different studies is due to the fact that SS respiratory symptoms are polymorphic and vary in severity. Some 9%-20% of patients with SS have clinically severe lung impairment. Pleural effusion in SS has an etiology that is unknown. It is thought to be caused by CD4+ T cells secreting cytokines that cause B lymphocytes to generate autoantibodies. High beta-2-microglobulin, which is secreted by lymphocytic tissue particularly in pulmonary SS, is another sign of lymphoproliferation in lung tissue. Our patient had recurrent pleural effusion due to lymphoproliferation in the lung as a result of SS.
摘要：
干燥综合征(SS)是一种以淋巴细胞外分泌腺浸润和多种全身症状为特征的全身性自身免疫性疾病。不同研究中报道的广泛流行是由于SS呼吸道症状是多态的并且严重程度不同。约9%-20%的SS患者具有临床上严重的肺损伤。SS的胸腔积液的病因未知。它被认为是由分泌细胞因子的CD4+T细胞引起的,所述细胞因子导致B淋巴细胞产生自身抗体。高β-2-微球蛋白，由淋巴细胞组织分泌，特别是在肺SS中，是肺组织淋巴增生的另一个迹象。由于SS导致肺部淋巴增生，我们的患者反复出现胸腔积液。
