PDF(Pubmed)
Abstract：
The microbiome\'s role in transplantation has received growing interest, but the role of virome remains understudied. Pegiviruses are single-stranded positive-sense RNA viruses, historically associated with liver disease, but their path-ogenicity is controversial. In the transplantation setting, pegivirus infection does not seem to have a negative impact on the outcomes of solid-organ and hematopoietic stem cell transplant recipients. However, the role of pegiviruses as proxies in immunosuppression monitoring brings novelty to the field of virome research in immunocompromised individuals. The possible immunomodulatory effect of pegivirus infections remains to be elucidated in further trials.
摘要：
微生物组在移植中的作用受到了越来越多的关注，但病毒蛋白的作用仍未得到充分研究。聚乙二醇病毒是单链正义RNA病毒，历史上与肝脏疾病相关，但它们的路径生成是有争议的。在移植环境中，pegivirus感染似乎对实体器官和造血干细胞移植受者的结局没有负面影响.然而,pegivirus在免疫抑制监测中作为代理的作用为免疫受损个体的病毒学研究领域带来了新颖性。猪病毒感染可能的免疫调节作用仍有待进一步试验阐明。
