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Abstract：
Acinic cell carcinoma (ACC) is a low or intermediate-grade malignant epithelial neoplasm of the salivary glands that generally shows an indolent behavior. Most cases arise in the major salivary glands, especially the parotid gland. ACC is usually known as a low-grade malignant tumor; however, poorly differentiated and high-grade transformed variants have been reported and may tend to be late recurrence and metastasis. Our case was a 49-year-old woman with a history of a right parotid rapidly growing mass lesion, which was cytologically diagnosed as monomorphic adenoma on fine-needle aspiration (FNA). Finally, the diagnosis of ACC with dedifferentiated components was reported, followed by parotidectomy. After 30 sessions of radiotherapy, she presented with hemifacial paresis. An imaging examination of the brain showed intracranial hemorrhage, and she underwent a craniotomy. We performed histopathological and immunohistochemical (IHC) examinations and diagnosed metastatic ACC with dedifferentiated components. Few ACC cases with dedifferentiated components and with aggressive behavior have been reported in the literature , and to the best of our knowledge, this article is the first English report in Iranian population.
摘要：
腺泡细胞癌（ACC）是唾液腺的低级或中级恶性上皮性肿瘤，通常表现出惰性行为。大多数病例出现在主要唾液腺，尤其是腮腺.ACC通常被称为低度恶性肿瘤；然而，已报道低分化和高级别转化变异体,可能倾向于晚期复发和转移.我们的病例是一名49岁的女性，有右腮腺快速增长的肿块病变史，细针穿刺（FNA）细胞学诊断为单形性腺瘤。最后,报告了具有去分化成分的ACC的诊断，其次是腮腺切除术。30次放疗后,她出现了半面轻瘫.脑部影像学检查显示颅内出血,她做了开颅手术.我们进行了组织病理学和免疫组织化学（IHC）检查，并诊断出具有去分化成分的转移性ACC。文献中很少报道具有去分化成分和攻击行为的ACC病例。据我们所知,这篇文章是伊朗人口的第一份英文报告。
