Abstract：
Scabies is a neglected tropical disease of the skin that can lead to impetigo, serious secondary bacterial infections and immune-mediated diseases. Mass drug administration (MDA) has been reported in several studies to reduce the prevalence of scabies and impetigo. We aimed to assess the efficacy of MDA for scabies on scabies and impetigo.
We conducted a systematic review and meta-analysis of reports on the impact of MDA on scabies and impetigo. We included randomized control trials and observational evaluations reported from January 1970 to April 2021 and involving human participants. We searched PubMed, Ovid Medline, Embase, and Cochrane. We considered MDA as treatment intended for the whole population, regardless of individual infection status or symptoms. The main outcome assessed was the change in scabies and impetigo prevalence following MDA. This review is registered with PROSPERO (CRD42020169839).
We identified 1110 records, of which 11 met inclusion criteria for the review and 9 were deemed suitable for meta-analysis for scabies and 4 for impetigo. Most studies were in small populations. There was a high degree of heterogeneity between studies (I2 value 96.19%). The overall relative reduction of the impact of MDA on scabies prevalence was 79%. The effect size was comparable for MDA based on ivermectin and permethrin. MDA for scabies also led to a reduction in impetigo prevalence with a relative reduction of 66%.
MDA for scabies is highly effective in reducing the prevalence of scabies and impetigo. Further research is needed to determine the durability of impact, and the effectiveness of MDA regimens in larger populations.
We conducted a systematic review and meta-analysis of reports on the impact of MDA on scabies and impetigo. We included randomized control trials and observational evaluations reported from January 1970 to April 2021 and involving human participants. We searched PubMed, Ovid Medline, Embase, and Cochrane. We considered MDA as treatment intended for the whole population, regardless of individual infection status or symptoms. The main outcome assessed was the change in scabies and impetigo prevalence following MDA. This review is registered with PROSPERO (CRD42020169839).
We identified 1110 records, of which 11 met inclusion criteria for the review and 9 were deemed suitable for meta-analysis for scabies and 4 for impetigo. Most studies were in small populations. There was a high degree of heterogeneity between studies (I2 value 96.19%). The overall relative reduction of the impact of MDA on scabies prevalence was 79%. The effect size was comparable for MDA based on ivermectin and permethrin. MDA for scabies also led to a reduction in impetigo prevalence with a relative reduction of 66%.
MDA for scabies is highly effective in reducing the prevalence of scabies and impetigo. Further research is needed to determine the durability of impact, and the effectiveness of MDA regimens in larger populations.
摘要：
镰刀菌是一种被忽视的热带性皮肤病，可导致脓疱病，严重的继发细菌感染和免疫介导的疾病。在几项研究中已经报道了大量药物施用（MDA）以降低sc疮和脓疱病的患病率。我们旨在评估MDA对sc疮和脓疱疮的疗效。
我们对MDA对sc疮和脓疱疮的影响进行了系统评价和荟萃分析。我们纳入了1970年1月至2021年4月报道的随机对照试验和观察性评估，涉及人类参与者。我们搜索了PubMed,OvidMedline,Embase,还有Cochrane.我们认为MDA是针对整个人群的治疗方法，无论个体感染状况或症状如何。评估的主要结果是MDA后sc疮和脓疱病患病率的变化。本评论在PROSPERO(CRD42020169839)注册。
我们确定了1110条记录,其中11项符合本综述的纳入标准,9项被认为适合用于c疮的荟萃分析,4项适合用于脓疱病的荟萃分析.大多数研究是在小人群中进行的。研究间存在高度异质性(I2值96.19%)。MDA对sc疮患病率的影响的总体相对降低为79％。基于伊维菌素和氯菊酯的MDA的效应大小相当。c疮的MDA还导致脓疱病患病率降低，相对降低了66％。
丙二醛对减少疮和脓疱疮的患病率非常有效。需要进一步的研究来确定冲击的耐久性，以及MDA方案在较大人群中的有效性。
我们对MDA对sc疮和脓疱疮的影响进行了系统评价和荟萃分析。我们纳入了1970年1月至2021年4月报道的随机对照试验和观察性评估，涉及人类参与者。我们搜索了PubMed,OvidMedline,Embase,还有Cochrane.我们认为MDA是针对整个人群的治疗方法，无论个体感染状况或症状如何。评估的主要结果是MDA后sc疮和脓疱病患病率的变化。本评论在PROSPERO(CRD42020169839)注册。
我们确定了1110条记录,其中11项符合本综述的纳入标准,9项被认为适合用于c疮的荟萃分析,4项适合用于脓疱病的荟萃分析.大多数研究是在小人群中进行的。研究间存在高度异质性(I2值96.19%)。MDA对sc疮患病率的影响的总体相对降低为79％。基于伊维菌素和氯菊酯的MDA的效应大小相当。c疮的MDA还导致脓疱病患病率降低，相对降低了66％。
丙二醛对减少疮和脓疱疮的患病率非常有效。需要进一步的研究来确定冲击的耐久性，以及MDA方案在较大人群中的有效性。
