Abstract:
Hyperglycaemia in pregnancy is one of the most common complications of pregnancy and is generally diagnosed as gestational diabetes mellitus (GDM). Nevertheless, clinical symptoms of hyperglycaemia in pregnancy in some cases do not match the clinical manifestations of GDM. It is suspected that 1-2 % of women diagnosed with GDM are misdiagnosed maturity-onset diabetes of the young (MODY). MODY often has a subclinical course; thus, it is challenging for clinicians to aptly diagnose monogenic diabetes in pregnancy. Proper diagnosis is crucial for the effective treatment of hyperglycaemia in pregnancy. Many studies revealed that misdiagnosis of MODY increases the rate of complications for both mother and fetus. This literature review reports the current knowledge regarding diagnosis, treatment, and complications of the most common types of MODY in pregnancy.
摘要:
妊娠期高血糖是最常见的妊娠并发症之一,通常被诊断为妊娠期糖尿病(GDM)。然而,在某些情况下,妊娠期高血糖的临床症状与GDM的临床表现不符。怀疑诊断为GDM的女性中有1-2%被误诊为年轻人的成熟型糖尿病(MODY)。MODY通常有亚临床课程;因此,临床医生在妊娠期正确诊断单基因糖尿病具有挑战性.正确的诊断对于有效治疗妊娠期高血糖症至关重要。许多研究表明,MODY的误诊会增加母亲和胎儿的并发症发生率。这篇文献综述报道了目前关于诊断的知识,治疗,以及妊娠期MODY最常见类型的并发症。