PDF(Pubmed)
Abstract：
Reactive oxygen species (ROS) are the key signaling molecules in many physiological signs of progress and are associated with almost all diseases, such as atherosclerosis, aging, and cancer. Bone is a specific connective tissue consisting of cells, fibers, and mineralized extracellular components, and its quality changes with aging and disease. Growing evidence indicated that overproduced ROS accumulation may disrupt cellular homeostasis in the progress of bone modeling and remodeling, leading to bone metabolic disease. Thus, ROS-responsive biomaterials have attracted great interest from many researchers as promising strategies to realize drug release or targeted therapy for bone-related diseases. Herein, we endeavor to introduce the role of ROS in the bone microenvironment, summarize the mechanism and development of ROS-responsive biomaterials, and their completion and potential for future therapy of bone-related diseases.
摘要：
活性氧（ROS）是许多生理过程中的关键信号分子，几乎与所有疾病有关。比如动脉粥样硬化，老化，和癌症。骨是由细胞组成的特定结缔组织，纤维，和矿化的细胞外成分，其质量随衰老和疾病而变化。越来越多的证据表明，过度产生的ROS积累可能会破坏骨骼建模和重塑过程中的细胞稳态。导致骨代谢疾病。因此，ROS响应性生物材料作为实现骨相关疾病的药物释放或靶向治疗的有希望的策略引起了许多研究人员的极大兴趣。在这里，我们努力介绍ROS在骨骼微环境中的作用，综述了ROS响应性生物材料的机制和发展，以及它们的完成和未来治疗骨相关疾病的潜力。
