PDF(Pubmed)
Abstract：
BACKGROUND: Many confounding factors such as sex, age, and body mass index (BMI) affect pulmonary function parameters, but there are limited data about the direct and/or indirect effects of small airway function on lung function for differences in confounding factors.
OBJECTIVE: This study aimed to use structural equation model (SEM) to explain the influence of the confounding factors (age, sex, and BMI) on the relationship between small airway function and lung function in patients with lung cancer.
METHODS: A cross-sectional observational study was conducted in a single medical center. Subjects were assessed; small airway function was specified by MEF25% and MEF50%; lung function by FVC; pulmonary obstruction by FEV1, FEV1%, and FEV1/FVC; and PEF and PEF% reflected the strength of abdominal muscles. The measurement model was analyzed by confirmatory factor analysis. The SEM was conducted to analyze the structural models of the effects of the confounding factors.
RESULTS: In the measurement model, variables were fit to their domains, the path linking age and sex to pulmonary obstruction was positive and statistically significant, and the path linking sex to muscle strength was also positive and statistically significant. Muscle strength positively and significantly mediates the path between sex and FVC. As a moderator, BMI increased the effects of small airway function on FVC.
CONCLUSIONS: Age and sex were directed to pulmonary obstruction, and muscle strength as a mediator between sex and lung function was novel, and BMI adjusted the effects of small airway function on FVC.
OBJECTIVE: This study aimed to use structural equation model (SEM) to explain the influence of the confounding factors (age, sex, and BMI) on the relationship between small airway function and lung function in patients with lung cancer.
METHODS: A cross-sectional observational study was conducted in a single medical center. Subjects were assessed; small airway function was specified by MEF25% and MEF50%; lung function by FVC; pulmonary obstruction by FEV1, FEV1%, and FEV1/FVC; and PEF and PEF% reflected the strength of abdominal muscles. The measurement model was analyzed by confirmatory factor analysis. The SEM was conducted to analyze the structural models of the effects of the confounding factors.
RESULTS: In the measurement model, variables were fit to their domains, the path linking age and sex to pulmonary obstruction was positive and statistically significant, and the path linking sex to muscle strength was also positive and statistically significant. Muscle strength positively and significantly mediates the path between sex and FVC. As a moderator, BMI increased the effects of small airway function on FVC.
CONCLUSIONS: Age and sex were directed to pulmonary obstruction, and muscle strength as a mediator between sex and lung function was novel, and BMI adjusted the effects of small airway function on FVC.
摘要：
背景：许多混杂因素，如性别，年龄,和体重指数（BMI）影响肺功能参数，但关于小气道功能对肺功能的直接和/或间接影响的混杂因素差异的数据有限。
目的：本研究旨在使用结构方程模型（SEM）来解释混杂因素（年龄，性别,和BMI）对肺癌患者小气道功能与肺功能的关系。
方法：在一个医疗中心进行了一项横断面观察性研究。评估受试者;MEF25%和MEF50%指定小气道功能;FVC指定肺功能;FEV1,FEV1%,和FEV1/FVC；PEF和PEF%反映腹部肌肉的力量。通过验证性因子分析对测量模型进行分析。进行了SEM分析，以分析混杂因素的影响的结构模型。
结果：在测量模型中，变量适合它们的领域，将年龄和性别与肺梗阻联系起来的路径是积极的，并且具有统计学意义，将性别与肌肉力量联系起来的路径也是积极的，并且具有统计学意义。肌肉力量在性别和FVC之间的路径中起着正向和显着的中介作用。作为主持人,BMI增加小气道功能对FVC的影响。
结论：年龄和性别与肺梗阻有关，肌肉力量作为性和肺功能之间的媒介是新颖的，BMI调整小气道功能对FVC的影响。
目的：本研究旨在使用结构方程模型（SEM）来解释混杂因素（年龄，性别,和BMI）对肺癌患者小气道功能与肺功能的关系。
方法：在一个医疗中心进行了一项横断面观察性研究。评估受试者;MEF25%和MEF50%指定小气道功能;FVC指定肺功能;FEV1,FEV1%,和FEV1/FVC；PEF和PEF%反映腹部肌肉的力量。通过验证性因子分析对测量模型进行分析。进行了SEM分析，以分析混杂因素的影响的结构模型。
结果：在测量模型中，变量适合它们的领域，将年龄和性别与肺梗阻联系起来的路径是积极的，并且具有统计学意义，将性别与肌肉力量联系起来的路径也是积极的，并且具有统计学意义。肌肉力量在性别和FVC之间的路径中起着正向和显着的中介作用。作为主持人,BMI增加小气道功能对FVC的影响。
结论：年龄和性别与肺梗阻有关，肌肉力量作为性和肺功能之间的媒介是新颖的，BMI调整小气道功能对FVC的影响。
