Abstract：
This cross-sectional study aimed to investigate the relationship between abdominal aortic calcification (AAC), which is a marker of vascular calcification, and volumetric bone mineral density (vBMD) by quantitative computed tomography (QCT) in maintenance hemodialysis (MHD) patients.
All participants underwent lumbar vertebral vBMD measurement by QCT. Eight cross-sections were extracted sequentially and analyzed by ImageJ software to obtain the ratio of the calcified area to the abdominal aortic area (the calcification ratio). The AAC score was determined by the sum of the calcification ratios. The relationship between AAC and vBMD was analyzed using multivariate logistic regression.
Ninety MHD patients (58.89% male) with a mean age of 63.43 (standard deviation [SD] = 13.20) years were included in the study. AAC was present (AAC score > 0) in 93.33% of the patients. The 75th percentile of the AAC score corresponding to 119 was used as the cutoff point between the mild and severe groups. After full adjustment in the logistic model, AAC was found to be inversely associated with vBMD (odds ratio [OR], 0.970; 95% confidence interval [CI], 0.944 to 0.996; P = 0.025), and patients with osteoporosis had a significantly higher risk of severe AAC than those with normal bone mass (OR, 14.498; 95% CI, 1.507 to 139.486; P = 0.021). The independent inverse association was still stable after adjusting for variables measured at different time periods and using different cutoff points of the AAC score.
There was an independent inverse association between AAC and vBMD, and osteoporosis was significantly associated with severe AAC in patients with MHD.
All participants underwent lumbar vertebral vBMD measurement by QCT. Eight cross-sections were extracted sequentially and analyzed by ImageJ software to obtain the ratio of the calcified area to the abdominal aortic area (the calcification ratio). The AAC score was determined by the sum of the calcification ratios. The relationship between AAC and vBMD was analyzed using multivariate logistic regression.
Ninety MHD patients (58.89% male) with a mean age of 63.43 (standard deviation [SD] = 13.20) years were included in the study. AAC was present (AAC score > 0) in 93.33% of the patients. The 75th percentile of the AAC score corresponding to 119 was used as the cutoff point between the mild and severe groups. After full adjustment in the logistic model, AAC was found to be inversely associated with vBMD (odds ratio [OR], 0.970; 95% confidence interval [CI], 0.944 to 0.996; P = 0.025), and patients with osteoporosis had a significantly higher risk of severe AAC than those with normal bone mass (OR, 14.498; 95% CI, 1.507 to 139.486; P = 0.021). The independent inverse association was still stable after adjusting for variables measured at different time periods and using different cutoff points of the AAC score.
There was an independent inverse association between AAC and vBMD, and osteoporosis was significantly associated with severe AAC in patients with MHD.
摘要：
这项横断面研究旨在探讨腹主动脉钙化(AAC)与这是血管钙化的标志，维持性血液透析（MHD）患者的定量计算机断层扫描（QCT）和体积骨矿物质密度（vBMD）。
所有参与者均通过QCT进行腰椎vBMD测量。依次提取8个横截面,通过ImageJ软件进行分析,得到钙化面积与腹主动脉面积的比值(钙化比)。通过钙化比率的总和确定AAC评分。采用多因素logistic回归分析AAC与vBMD的关系。
90名MHD患者（58.89%为男性），平均年龄为63.43岁（标准差[SD]=13.20）。93.33%的患者存在AAC(AAC评分>0)。对应于119的AAC评分的第75百分位数用作轻度组和重度组之间的截止点。在逻辑模型中进行充分调整后，发现AAC与vBMD呈负相关(比值比[OR]，0.970；95%置信区间[CI]，0.944至0.996；P=0.025），骨质疏松症患者发生严重AAC的风险明显高于骨量正常的患者（OR，14.498；95%CI，1.507～139.486；P=0.021）。在调整了在不同时间段测量的变量并使用AAC评分的不同截止点后，独立的逆关联仍然稳定。
AAC和vBMD之间存在独立的逆关联，骨质疏松与MHD患者的严重AAC显著相关。
所有参与者均通过QCT进行腰椎vBMD测量。依次提取8个横截面,通过ImageJ软件进行分析,得到钙化面积与腹主动脉面积的比值(钙化比)。通过钙化比率的总和确定AAC评分。采用多因素logistic回归分析AAC与vBMD的关系。
90名MHD患者（58.89%为男性），平均年龄为63.43岁（标准差[SD]=13.20）。93.33%的患者存在AAC(AAC评分>0)。对应于119的AAC评分的第75百分位数用作轻度组和重度组之间的截止点。在逻辑模型中进行充分调整后，发现AAC与vBMD呈负相关(比值比[OR]，0.970；95%置信区间[CI]，0.944至0.996；P=0.025），骨质疏松症患者发生严重AAC的风险明显高于骨量正常的患者（OR，14.498；95%CI，1.507～139.486；P=0.021）。在调整了在不同时间段测量的变量并使用AAC评分的不同截止点后，独立的逆关联仍然稳定。
AAC和vBMD之间存在独立的逆关联，骨质疏松与MHD患者的严重AAC显著相关。
