Abstract：
We aimed to explore the association between estimated glomerular filtration rate (eGFR) and prognosis in patients with diabetic foot osteomyelitis (DFO). Three hundred twenty-one DFO inpatients were enrolled and classified into four groups according to the eGFRs as follows: normal (≥90), mildly reduced (60-89), moderately reduced (30-59) and severely reduced (<30). These patients were followed-up for 6 months to observe the outcomes, including ulcer healing and amputation. The associations between eGFR and the outcomes were analysed by univariate and multivariate logistic regression models. Compared with patients with normal eGFR, patients with severely reduced eGFR group had higher risk of healing failure (OR = 4.72, 95% CI: 1.44-15.48), total amputation (OR = 4.50, 95% CI: 1.18-17.13) and minor amputation (OR = 4.05, 95% CI: (1.04-15.87). Severely reduced eGFR in patients with DFO was an independent predictor for amputation and healing failure.
摘要：
我们旨在探讨估计肾小球滤过率（eGFR）与糖尿病足骨髓炎（DFO）患者预后之间的关系。纳入了321例DFO住院患者，并根据eGFR分为四组：正常（≥90），轻度减少（60-89），适度减少（30-59）和严重减少（<30）。对这些患者进行6个月的随访观察,包括溃疡愈合和截肢。通过单变量和多变量逻辑回归模型分析eGFR与结果之间的关联。与eGFR正常的患者相比，eGFR严重降低组患者愈合失败的风险较高(OR=4.72,95%CI:1.44-15.48),完全截肢(OR=4.50,95%CI:1.18-17.13)和轻微截肢(OR=4.05,95%CI:(1.04-15.87)。DFO患者eGFR严重降低是截肢和愈合失败的独立预测因素。
