Abstract：
OBJECTIVE: Overexpression of mucin1 is found in head and neck squamous cell carcinoma tissues compared with adjacent non-neoplastic tissues and higher levels are associated with metastasis and invasion. The expression level of mucin1 in saliva of normal individuals, oral potentially malignant disorders and oral squamous cell carcinoma patients and its correlation to clinical and histological variables was evaluated.
METHODS: Forty oral potentially malignant disorders, 40 oral squamous cell carcinoma subjects, and 20 age matched-controls were included. Stimulated salivary samples were collected from all participants, and mucin1 expression was measured by real-time PCR.
RESULTS: Mucin1 expression in saliva was significantly elevated in oral potentially malignant disorders when compared with controls. Similarly, mucin1 expression was significantly elevated in oral squamous cell carcinoma group when compared with oral potentially malignant disorders and controls. Mucin1 expression in OSCC patient showed significant positive correlations with T classification and distant Metastasis. Mucin1 expression in oral potentially malignant disorders patients showed significant positive correlations with degree of dysplasia.
CONCLUSIONS: The expression level of mucin1 in saliva might be a potential biomarker for diagnosing oral potentially malignant disorders and oral squamous cell carcinoma.
METHODS: Forty oral potentially malignant disorders, 40 oral squamous cell carcinoma subjects, and 20 age matched-controls were included. Stimulated salivary samples were collected from all participants, and mucin1 expression was measured by real-time PCR.
RESULTS: Mucin1 expression in saliva was significantly elevated in oral potentially malignant disorders when compared with controls. Similarly, mucin1 expression was significantly elevated in oral squamous cell carcinoma group when compared with oral potentially malignant disorders and controls. Mucin1 expression in OSCC patient showed significant positive correlations with T classification and distant Metastasis. Mucin1 expression in oral potentially malignant disorders patients showed significant positive correlations with degree of dysplasia.
CONCLUSIONS: The expression level of mucin1 in saliva might be a potential biomarker for diagnosing oral potentially malignant disorders and oral squamous cell carcinoma.
摘要：
目的：头颈部鳞状细胞癌组织中黏蛋白1的过表达高于癌旁非肿瘤组织，且较高的表达水平与转移和侵袭有关。正常个体唾液中黏蛋白1的表达水平,评估了口腔潜在恶性疾病和口腔鳞状细胞癌患者及其与临床和组织学变量的相关性。
方法：40种口腔潜在恶性疾病，40名口腔鳞状细胞癌受试者，纳入20例年龄匹配的对照.从所有参与者收集刺激的唾液样本，通过实时PCR检测粘蛋白1的表达。
结果：与对照组相比，口腔潜在恶性疾病中唾液粘蛋白1的表达显著升高。同样，与口腔潜在恶性疾病和对照组相比，口腔鳞状细胞癌组的粘蛋白1表达显着升高。OSCC患者的粘蛋白1表达与T分类和远处转移呈显着正相关。口腔潜在恶性疾病患者的粘蛋白1表达与发育不良程度呈显着正相关。
结论：唾液中黏蛋白1的表达水平可能是诊断口腔潜在恶性疾病和口腔鳞状细胞癌的潜在生物标志物。
方法：40种口腔潜在恶性疾病，40名口腔鳞状细胞癌受试者，纳入20例年龄匹配的对照.从所有参与者收集刺激的唾液样本，通过实时PCR检测粘蛋白1的表达。
结果：与对照组相比，口腔潜在恶性疾病中唾液粘蛋白1的表达显著升高。同样，与口腔潜在恶性疾病和对照组相比，口腔鳞状细胞癌组的粘蛋白1表达显着升高。OSCC患者的粘蛋白1表达与T分类和远处转移呈显着正相关。口腔潜在恶性疾病患者的粘蛋白1表达与发育不良程度呈显着正相关。
结论：唾液中黏蛋白1的表达水平可能是诊断口腔潜在恶性疾病和口腔鳞状细胞癌的潜在生物标志物。
