关键词: en bloc transmission extracellular vesicles hijacking viruses

Mesh : Extracellular Vesicles / metabolism Humans Immune Evasion Polyomavirus Viruses

来  源:   DOI:10.1684/vir.2021.0923

Abstract:
There is a close relationship between viruses and lipid vesicles. The most frequently described concerns enveloped viruses, which acquire their envelope through mechanisms involved in extracellular vesicles (EVs) biogenesis. However, EVs\' hijacking is not unique to enveloped viruses. In 2013, a new category of viruses emerged : the quasi-enveloped viruses. These are naked viruses found in vesicles at certain steps of their viral cycle. Actually, several naked viruses, from different families, hijack the production routes of EVs : poliovirus, polyomaviruses, rotavirus, etc. This diversion of EVs confers many advantages : diversification of entry and exit pathways, infectivity improvement and immune evasion. This review will take the reader around this subject.
摘要:
病毒与脂质囊泡之间存在着密切的关系。最常描述的是包膜病毒,它们通过参与细胞外囊泡(EV)生物发生的机制获得包膜。然而,电动汽车劫持并不是包膜病毒独有的。2013年,出现了一类新的病毒:准包膜病毒。这些是在其病毒循环的某些步骤中在囊泡中发现的裸病毒。事实上,几个赤裸的病毒,来自不同的家庭,劫持电动汽车的生产路线:脊髓灰质炎病毒,多瘤病毒,轮状病毒,等。电动汽车的这种转移赋予了许多优势:进入和退出途径的多样化,传染性改善和免疫逃避。这篇评论将带读者围绕这个主题。
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