Abstract：
OBJECTIVE: Platelet-rich plasma (PRP) is widely used for wound healing in medical care because of the numerous growth factors it contains. Traditionally, donor sites are left to heal with a primary dressing so wounds are not left open. However, a delay in healing accompanied by pain at a donor site is often seen. This study primarily throws light on the use of autologous PRP over split-thickness skin graft (STSG) donor sites to promote healing and reduce pain.
METHODS: The patients enrolled in this study in 2018-2019 were divided into two groups: the intervention group received autologous PRP applied topically at the donor site; in the control group, the wound was dressed traditionally. Pain scales were measured in the immediate postoperative period at six hours, 10 hours and 16 hours. The dressing was opened on the postoperative day 14 and observed for healing by an independent observer.
RESULTS: A total of 100 patients were included in the study. Patients in the PRP group showed statistically significant faster healing at postoperative day 14 compared with the control group (p<0.05), who required dressings for 3-4 weeks postoperatively. Pain scale scores in the postoperative period were significantly less in the PRP group at six hours postoperatively compared with the control group (p<0.05). There was a reduced incidence of hypertrophic scar formation in the small number of patients in the PRP group who had developed hypertrophic scar previously.
CONCLUSIONS: Application of PRP is a safe, cost-effective and easy method to achieve faster healing in graft donor site areas that are troublesome to both patients and doctors. It also reduces postoperative pain at donor sites. The authors recommend PRP is used more often in the management of donor sites for STSGs.
METHODS: The patients enrolled in this study in 2018-2019 were divided into two groups: the intervention group received autologous PRP applied topically at the donor site; in the control group, the wound was dressed traditionally. Pain scales were measured in the immediate postoperative period at six hours, 10 hours and 16 hours. The dressing was opened on the postoperative day 14 and observed for healing by an independent observer.
RESULTS: A total of 100 patients were included in the study. Patients in the PRP group showed statistically significant faster healing at postoperative day 14 compared with the control group (p<0.05), who required dressings for 3-4 weeks postoperatively. Pain scale scores in the postoperative period were significantly less in the PRP group at six hours postoperatively compared with the control group (p<0.05). There was a reduced incidence of hypertrophic scar formation in the small number of patients in the PRP group who had developed hypertrophic scar previously.
CONCLUSIONS: Application of PRP is a safe, cost-effective and easy method to achieve faster healing in graft donor site areas that are troublesome to both patients and doctors. It also reduces postoperative pain at donor sites. The authors recommend PRP is used more often in the management of donor sites for STSGs.
摘要：
目的：富血小板血浆（PRP）由于含有多种生长因子，在医疗护理中广泛用于伤口愈合。传统上,供体部位用主要敷料愈合，因此伤口不会开放。然而,通常会看到愈合延迟并伴有供体部位的疼痛。这项研究主要介绍了在分层厚度皮肤移植物（STSG）供体部位上使用自体PRP以促进愈合和减轻疼痛。
方法：将2018-2019年纳入本研究的患者分为两组：干预组在供体部位局部应用自体PRP；对照组，伤口是传统的包扎方式。在术后6小时测量疼痛评分，10小时和16小时在术后第14天打开敷料并由独立观察者观察愈合。
结果：本研究共纳入100例患者。与对照组相比，PRP组患者在术后第14天的愈合速度有统计学意义（p<0.05），术后3-4周需要敷料。PRP组术后6h疼痛评分明显低于对照组(p<0.05)。PRP组中少数先前出现过肥厚性瘢痕的患者中，肥厚性瘢痕形成的发生率降低。
结论：应用PRP是安全的，成本有效和简单的方法，以实现更快的愈合移植供体部位，这是给患者和医生带来麻烦。它还可以减少供体部位的术后疼痛。作者建议PRP更常用于STSG的供体位点的管理。
方法：将2018-2019年纳入本研究的患者分为两组：干预组在供体部位局部应用自体PRP；对照组，伤口是传统的包扎方式。在术后6小时测量疼痛评分，10小时和16小时在术后第14天打开敷料并由独立观察者观察愈合。
结果：本研究共纳入100例患者。与对照组相比，PRP组患者在术后第14天的愈合速度有统计学意义（p<0.05），术后3-4周需要敷料。PRP组术后6h疼痛评分明显低于对照组(p<0.05)。PRP组中少数先前出现过肥厚性瘢痕的患者中，肥厚性瘢痕形成的发生率降低。
结论：应用PRP是安全的，成本有效和简单的方法，以实现更快的愈合移植供体部位，这是给患者和医生带来麻烦。它还可以减少供体部位的术后疼痛。作者建议PRP更常用于STSG的供体位点的管理。
