Abstract：
The significant increase in the number of antibiotic-resistant microorganisms observed in recent years is a public health problem worldwide. One of the molecular mechanisms for the formation of antimicrobial resistance in bacteria is the presence of efflux pumps. The review presents an analysis of experimental studies related to the study of efflux pumps in clinical strains of Pseudomonas aeruginosa, one of the representatives of hospital pathogens of the ESKAPE group. This review is intended for specialists developing new types of drugs against antibiotic-resistant strains, as well as researchers studying the mechanisms of bacterial resistance to antibiotics, heavy metals, biocides and other antimicrobial factors.
摘要：
近年来观察到的抗生素抗性微生物数量的显著增加是世界范围内的公共卫生问题。在细菌中形成抗微生物抗性的分子机制之一是外排泵的存在。该综述提供了与铜绿假单胞菌临床菌株外排泵研究相关的实验研究分析，ESKAPE组医院病原体的代表之一。这篇综述旨在为专家开发针对抗生素耐药菌株的新型药物，以及研究细菌对抗生素耐药机制的研究人员，重金属,杀菌剂和其他抗菌因子。
