Abstract：
This study explores a combined electrochemical and spectroscopic approach to investigate the degradation of bilirubin, a molecular marker of jaundice in humans using a biocompatible nanohybrid (citrate-functionalized Mn3 O4 nanohybrid; C-Mn3 O4 NH). The approach is aimed at the development of a facile theranostic tool for treatment, detection, and prognosis of jaundice. Linear sweep voltammetry (LSV) studies on bilirubin, C-Mn3 O4 NH, a model carrier protein, and its complex with bilirubin reveal the efficacy of the nanohybrid for both degradation and detection of bilirubin. Furthermore, spectroscopic studies depict that distal electron transfer to be the probable mechanism behind the observed bilirubin degradation in physiological milieu.
摘要：
本研究探索了一种电化学和光谱相结合的方法来研究胆红素的降解，使用生物相容性纳米杂化物（柠檬酸盐官能化的Mn3O4纳米杂化物；C-Mn3O4NH）的人类黄疸的分子标记。该方法旨在开发一种简便的治疗工具，检测,黄疸的预后。线性扫描伏安法（LSV）研究胆红素，C-Mn3O4NH,一种模型载体蛋白，及其与胆红素的复合物揭示了纳米杂交体降解和检测胆红素的功效。此外，光谱研究表明，远端电子转移是生理环境中观察到的胆红素降解背后的可能机制。
