PDF(Pubmed)
Abstract：
BACKGROUND: To describe the clinical, diagnostic imaging, and histopathological findings of two visually impaired closely related horses and to identify a possible cause.
METHODS: Two warmblood horses, with a common dam and sire, were presented to the ophthalmology department of Liège for investigation of impaired vision. Information collected included physical and ophthalmic examination findings, results of ocular ultrasound, electroretinogram, magnetic resonance imaging (MRI), and histopathology. Ophthalmic examination, ocular ultrasound and MRI revealed a complete retinal detachment (RD) in the left eye and vitreous synaeresis in both eyes of both horses. Electroretinograms showed a normal response in both right eyes but a total loss of the retinal response in their left eyes. Histopathologic examination revealed multifocal retinal dysplasia in both left eyes.
CONCLUSIONS: In these two horses, RD has likely been caused by the congenital posterior segment abnormalities of the vitreous and the retina. A vitreoretinopathy is highly suspected and is possibly hereditary in these closely related siblings.
METHODS: Two warmblood horses, with a common dam and sire, were presented to the ophthalmology department of Liège for investigation of impaired vision. Information collected included physical and ophthalmic examination findings, results of ocular ultrasound, electroretinogram, magnetic resonance imaging (MRI), and histopathology. Ophthalmic examination, ocular ultrasound and MRI revealed a complete retinal detachment (RD) in the left eye and vitreous synaeresis in both eyes of both horses. Electroretinograms showed a normal response in both right eyes but a total loss of the retinal response in their left eyes. Histopathologic examination revealed multifocal retinal dysplasia in both left eyes.
CONCLUSIONS: In these two horses, RD has likely been caused by the congenital posterior segment abnormalities of the vitreous and the retina. A vitreoretinopathy is highly suspected and is possibly hereditary in these closely related siblings.
摘要：
背景：为了描述临床，诊断成像,以及两匹视障密切相关马的组织病理学发现，并确定可能的原因。
方法：两匹热血马，有一个共同的大坝和陛下，被送到列日眼科进行视力受损的调查。收集的信息包括身体和眼科检查结果，眼超声结果，视网膜电图,磁共振成像（MRI），和组织病理学。眼科检查,眼部超声和MRI显示左眼完全视网膜脱离（RD），两匹马的双眼均出现玻璃体分离。视网膜电图显示两只右眼的反应正常，但左眼的视网膜反应完全丧失。组织病理学检查显示左眼多灶性视网膜发育不良。
结论：在这两匹马中，RD可能是由玻璃体和视网膜的先天性后段异常引起的。高度怀疑玻璃体视网膜病变，并且在这些密切相关的兄弟姐妹中可能是遗传性的。
方法：两匹热血马，有一个共同的大坝和陛下，被送到列日眼科进行视力受损的调查。收集的信息包括身体和眼科检查结果，眼超声结果，视网膜电图,磁共振成像（MRI），和组织病理学。眼科检查,眼部超声和MRI显示左眼完全视网膜脱离（RD），两匹马的双眼均出现玻璃体分离。视网膜电图显示两只右眼的反应正常，但左眼的视网膜反应完全丧失。组织病理学检查显示左眼多灶性视网膜发育不良。
结论：在这两匹马中，RD可能是由玻璃体和视网膜的先天性后段异常引起的。高度怀疑玻璃体视网膜病变，并且在这些密切相关的兄弟姐妹中可能是遗传性的。
