PDF(Pubmed)
Abstract：
Nasopharyngeal carcinoma (NPC) is an epithelial tumor, which develops most frequently from the lateral pharyngeal recess and holds some complex epidemiological characteristics. Its unusual race and geographic distribution suggests that not only the environmental factors are a contributing factor to the development of this rare cancer type, but also the genetic traits play an important role, along with nitrosamine-containing food consumption and Epstein-Barr virus infection. The signs and symptoms which a patient can present and suffer from are various and include nasal, otic, neurological as well as general ones; the way this tumor manifests being dependent on the stage of the tumor. The therapeutic management applicable in NPC needs to be established according to the case of the patient and include radiotherapy, chemotherapy, surgery, immune therapy, targeted therapy or combined treatment. The main objective of the treatment is local and regional tumor control; relapse is an important factor for future development of distant metastases. New therapeutic concepts are always sought of, current research focusing on precision medicine, meaning systemic treatment with a personalized radiotherapy approach according to the characteristics of the tumor.
摘要：
鼻咽癌（NPC）是一种上皮性肿瘤，最常见的是从咽侧隐窝发展，并具有一些复杂的流行病学特征。其不寻常的种族和地理分布表明，不仅环境因素是这种罕见癌症类型发展的促成因素，而且遗传性状也起着重要的作用，以及含有亚硝胺的食物消费和EB病毒感染。患者可以呈现和遭受的体征和症状是各种各样的，包括鼻，otic,神经和一般；这种肿瘤的表现方式取决于肿瘤的阶段。适用于NPC的治疗管理需要根据患者的情况建立，包括放疗，化疗,手术,免疫疗法,靶向治疗或联合治疗。治疗的主要目的是局部和区域肿瘤控制；复发是远处转移未来发展的重要因素。一直在寻求新的治疗概念，目前专注于精准医学的研究，意味着根据肿瘤的特点，采用个性化的放射治疗方法进行全身治疗。
