Abstract：
Cardiovascular diseases (CVDs) are now the leading cause of mortality and morbidity worldwide，resulting in a large global economic burden. Recently, complementary and alternative medicine, such as traditional Chinese medicine (TCM) have received great attention. Puerarin (Pue) is an isoflavone isolated from the roots of Pueraria lobata (Willd.) Ohwi (also named \"Ge gen\" in China), and is a versatile TCM herb used for the treatment of fever, diarrhea, diabetes mellitus CVDs and cerebrovascular diseases. Numerous lines ofin vitro studies, as well as in vivo animal experiments have established that Pue offers beneficial roles against the progression of atherosclerosis, ischemic heart diseases, heart failure hypertension and arrhythmia by inhibiting pathological processes, such as the mitigation of endothelium injury, protection against inflammation, the disturbance of lipid metabolism, protection against ischemic reperfusion injury, anti-myocardial remodeling and other effects. Here, we provide a systematic overview of the pharmacological actions and molecular targets of Pue in cardiovascular disease prevention and treatment, to provide insights into the therapeutic potential of Pue in treating cardiovascular diseases.
摘要：
心血管疾病（CVDs）是目前世界范围内导致死亡和发病的主要原因，给全球带来了巨大的经济负担。最近,补充和替代医学，如中药（TCM）受到了极大的关注。葛根素（Pue）是从葛根（Willd。)Ohwi(在中国也被称为“葛根”)，是一种用于治疗发烧的多功能中药，腹泻,糖尿病和脑血管疾病。大量的体外研究，以及体内动物实验已经确定，Pue提供了有益的作用，防止动脉粥样硬化的进展，缺血性心脏病,心力衰竭高血压和心律失常通过抑制病理过程，如减轻内皮损伤，防止炎症，脂质代谢紊乱，保护缺血再灌注损伤，抗心肌重塑等作用。这里,我们对Pue在心血管疾病预防和治疗中的药理作用和分子靶点进行了系统的概述，提供对Pue在治疗心血管疾病方面的治疗潜力的见解。
