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Abstract：
BACKGROUND: Electrolyzed hydrogen-rich water (EHW) is known to have suppressive effects on oxidative stress (OS). However, its benefit in type 2 diabetes mellitus (T2DM) remains unclear. This study aimed to investigate the effect of EHW on T2DM.
METHODS: This was a multicenter, prospective, double-blind, randomized controlled trial of 50 patients with T2DM who were assigned to the EHW or filtered water (FW) groups. The primary endpoint was changes in insulin resistance (IR) evaluated using the homeostasis model assessment of insulin resistance (HOMA-IR). OS markers such as urinary 8-hydroxy-2\'-deoxyguanosine excretion (8-OHdG), plasma diacron-reactive oxygen metabolites (d-ROM), and plasma biological antioxidant potential (BAP) and other clinical data, including serum lactate concentration (lactate), were evaluated.
RESULTS: There were no significant differences in the changes in HOMA-IR between the EHW and FW groups. However, lactate levels decreased significantly in the EHW group, and this decrease was significantly correlated with a reduction in HOMA-IR, fasting plasma glucose, and fasting plasma insulin level. Serum lactate level also significantly correlated to decreased insulin bolus secretion after 90 min with glucose loading in the EHW subjects with HOMA-IR > 1.73. No EHW treatment-related adverse effects were observed.
CONCLUSIONS: There were no significant effect of EHW in the change in HOMA-IR in this study; larger-scale and longer-term study are needed to verify the effects of EHW in T2DM patients.
BACKGROUND: The online version contains supplementary material available at 10.1007/s13340-021-00524-3.
METHODS: This was a multicenter, prospective, double-blind, randomized controlled trial of 50 patients with T2DM who were assigned to the EHW or filtered water (FW) groups. The primary endpoint was changes in insulin resistance (IR) evaluated using the homeostasis model assessment of insulin resistance (HOMA-IR). OS markers such as urinary 8-hydroxy-2\'-deoxyguanosine excretion (8-OHdG), plasma diacron-reactive oxygen metabolites (d-ROM), and plasma biological antioxidant potential (BAP) and other clinical data, including serum lactate concentration (lactate), were evaluated.
RESULTS: There were no significant differences in the changes in HOMA-IR between the EHW and FW groups. However, lactate levels decreased significantly in the EHW group, and this decrease was significantly correlated with a reduction in HOMA-IR, fasting plasma glucose, and fasting plasma insulin level. Serum lactate level also significantly correlated to decreased insulin bolus secretion after 90 min with glucose loading in the EHW subjects with HOMA-IR > 1.73. No EHW treatment-related adverse effects were observed.
CONCLUSIONS: There were no significant effect of EHW in the change in HOMA-IR in this study; larger-scale and longer-term study are needed to verify the effects of EHW in T2DM patients.
BACKGROUND: The online version contains supplementary material available at 10.1007/s13340-021-00524-3.
摘要：
背景：已知电解富氢水（EHW）对氧化应激（OS）具有抑制作用。然而,其在2型糖尿病(T2DM)中的获益仍不清楚.本研究旨在探讨EHW对T2DM的影响。
方法：这是一个多中心，prospective,双盲,纳入50例T2DM患者的随机对照试验,这些患者被分配到EHW或过滤水(FW)组.主要终点是使用胰岛素抵抗的稳态模型评估（HOMA-IR）评估的胰岛素抵抗（IR）的变化。OS标记如尿8-羟基-2'-脱氧鸟苷排泄（8-OHdG），血浆涤纶活性氧代谢产物（d-ROM），和血浆生物抗氧化潜能（BAP）和其他临床数据，包括血清乳酸浓度（乳酸），进行了评估。
结果：EHW组和FW组之间的HOMA-IR变化没有显着差异。然而,EHW组的乳酸水平显着下降，这种减少与HOMA-IR的减少显着相关，空腹血糖，和空腹血浆胰岛素水平。在HOMA-IR>1.73的EHW受试者中,血清乳酸水平也与葡萄糖负荷90分钟后胰岛素推注分泌减少显著相关。未观察到EHW治疗相关的不良反应。
结论：本研究中，EHW对HOMA-IR的变化没有显著影响；需要更大规模和更长期的研究来验证EHW对T2DM患者的影响。
背景：在线版本包含10.1007/s13340-021-00524-3提供的补充材料。
方法：这是一个多中心，prospective,双盲,纳入50例T2DM患者的随机对照试验,这些患者被分配到EHW或过滤水(FW)组.主要终点是使用胰岛素抵抗的稳态模型评估（HOMA-IR）评估的胰岛素抵抗（IR）的变化。OS标记如尿8-羟基-2'-脱氧鸟苷排泄（8-OHdG），血浆涤纶活性氧代谢产物（d-ROM），和血浆生物抗氧化潜能（BAP）和其他临床数据，包括血清乳酸浓度（乳酸），进行了评估。
结果：EHW组和FW组之间的HOMA-IR变化没有显着差异。然而,EHW组的乳酸水平显着下降，这种减少与HOMA-IR的减少显着相关，空腹血糖，和空腹血浆胰岛素水平。在HOMA-IR>1.73的EHW受试者中,血清乳酸水平也与葡萄糖负荷90分钟后胰岛素推注分泌减少显著相关。未观察到EHW治疗相关的不良反应。
结论：本研究中，EHW对HOMA-IR的变化没有显著影响；需要更大规模和更长期的研究来验证EHW对T2DM患者的影响。
背景：在线版本包含10.1007/s13340-021-00524-3提供的补充材料。
