PDF(Pubmed)
Abstract：
Legionella pneumophila (L. pneumophila) is a pathogenic bacterium of increasing concern, due to its ability to cause a severe pneumonia, Legionnaires\' Disease (LD), and the challenges in controlling the bacteria within premise plumbing systems. L. pneumophila can thrive within the biofilm of premise plumbing systems, utilizing protozoan hosts for protection from environmental stressors and to increase its growth rate, which increases the bacteria\'s infectivity to human host cells. Typical disinfectant techniques have proven to be inadequate in controlling L. pneumophila in the premise plumbing system, exposing users to LD risks. As the bacteria have limited infectivity to human macrophages without replicating within a host protozoan cell, the replication within, and egress from, a protozoan host cell is an integral part of the bacteria\'s lifecycle. While there is a great deal of information regarding how L. pneumophila interacts with protozoa, the ability to use this data in a model to attempt to predict a concentration of L. pneumophila in a water system is not known. This systematic review summarizes the information in the literature regarding L. pneumophila\'s growth within and egress from the host cell, summarizes the genes which affect these processes, and calculates how oxidative stress can downregulate those genes.
摘要：
嗜肺军团菌（L.嗜肺）是一种日益受到关注的致病菌，由于其引起严重肺炎的能力，军团病（LD），以及控制前提管道系统中细菌的挑战。肺炎杆菌可以在前提管道系统的生物膜中茁壮成长，利用原生动物宿主保护免受环境压力并提高其生长速度，这增加了细菌对人类宿主细胞的感染性。事实证明，典型的消毒剂技术不足以控制前提管道系统中的嗜肺乳杆菌，使用户面临LD风险。由于细菌对人类巨噬细胞的感染性有限，而不会在宿主原生动物细胞内复制，内部的复制，和出口，原生动物宿主细胞是细菌生命周期中不可或缺的一部分。虽然有大量关于嗜肺乳杆菌如何与原生动物相互作用的信息，在模型中使用这些数据来尝试预测水系统中嗜肺乳杆菌浓度的能力尚不清楚。本系统综述总结了文献中有关肺炎杆菌在宿主细胞内生长和从宿主细胞中流出的信息，总结了影响这些过程的基因，并计算氧化应激如何下调这些基因。
