Abstract：
Gurltia paralysans, a metastrongyloid nematode, parasitizes in meningeal vessels in the thoracolumbar spinal cord of cats in South America and causes progressive paraparesis. Recently, the first report outside of South America described gurltiosis in a cat in Spain. As this parasitic disease has so far been largely neglected, especially outside of South America, the aim of the present case study was to add knowledge to the histologic and immunohistochemical characterization of central nervous lesions. To this purpose, formalin-fixed and paraffin-embedded (FFPE) tissue samples from the spinal cord and brain of five cats affected by clinical signs caused by Gurltia paralysans and of three control cats without CNS lesions were histopathologically examined using hematoxylin and eosin stain (HE), Elastica van Gieson stain, as well as periodic acid-Schiff (PAS) reaction. Moreover, immuno- histochemistry for alpha smooth muscle actin and Factor VIII-related antigen were performed to characterize vascular lesions. Lesions were consistent with previous descriptions and were mainly located in the spinal cord and consisted of chronic suppurative or lymphoplasmahistiocytic meningi tis as well as suppurative vasculitis, congestion and varicosis of meningeal veins. In view of the recent detection of this parasite in Europe and the increasing inner-European transport of rescued domestic cats, veterinarians in Europe should be aware of the clinical and pathomorphological presentation of this disease.
摘要：
Gurltia麻痹者，一种中圆线虫，在南美猫的胸腰椎脊髓的脑膜血管中寄生，并引起进行性轻瘫。最近,南美以外的第一份报告描述了西班牙一只猫的骨病。由于这种寄生虫病到目前为止在很大程度上被忽视了，尤其是在南美洲以外的地方，本病例研究的目的是增加中枢神经病变的组织学和免疫组织化学特征的知识。为此,使用苏木精和曙红染色（HE）对五只猫的脊髓和大脑中的福尔马林固定和石蜡包埋（FFPE）组织样本进行了组织病理学检查，其中五只猫受到Gurltia麻痹引起的临床体征的影响，三只没有中枢神经系统病变的对照猫，ElasticavanGieson污点,以及高碘酸-希夫（PAS）反应。此外，对α平滑肌肌动蛋白和因子VIII相关抗原进行免疫组织化学,以表征血管病变的特征.病变与以前的描述一致，主要位于脊髓，包括慢性化脓性或淋巴浆细胞性脑膜炎以及化脓性血管炎，脑膜静脉充血和静脉曲张。鉴于最近在欧洲发现了这种寄生虫，以及被拯救的家猫在欧洲内部的运输不断增加，欧洲的兽医应该了解这种疾病的临床和病理形态学表现。
