关键词: COVID-19 SARS-CoV-2 embryos endometrium female reproductive system follicular fluid in vitro fertilization menstrual cycle oocytes ovarian reserve

Mesh : COVID-19 Female Humans Oocytes Ovarian Reserve RNA, Viral SARS-CoV-2

来  源:   DOI:10.3390/ijerph19020984

Abstract:
As the coronavirus pandemic is far from ending, more questions regarding the female reproductive system, particularly fertility issues, arise. The purpose of this paper is to bring light upon the possible link between COVID-19 and women\'s reproductive health. This review emphasizes the effect of SARS-CoV-2 on the hormones, endometrium and menstrual cycle, ovarian reserve, follicular fluid, oocytes, and embryos. The results showed that endometrial samples did not express SARS-CoV-2 RNA. Regarding the menstrual cycle, there is a large range of alterations, but they were all reversible within the following months. The ovarian reserve was not significantly affected in patients recovering from both mild and severe infection in most cases, except one, where the levels of AMH were significantly lower and basal follicle-stimulating hormone (FSH) levels were increased. All COVID-19 recovered patients had positive levels of SARS-CoV-2 IgG in the follicular fluid. The amount of retrieved and mature oocytes and the fertilization rate were unharmed in three studies, except for one study, where the quantity of retrieved and mature oocytes was reduced in patients with higher levels of SARS-CoV-2 antibodies. The numbers of blastocysts, top-quality embryos, and euploid embryos were affected in most of the studies reviewed.
摘要:
由于冠状病毒大流行远未结束,更多关于女性生殖系统的问题,特别是生育问题,出现。本文的目的是揭示COVID-19与女性生殖健康之间的可能联系。这篇综述强调了SARS-CoV-2对激素的影响,子宫内膜和月经周期,卵巢储备,卵泡液,卵母细胞,和胚胎。结果显示子宫内膜样品不表达SARS-CoV-2RNA。关于月经周期,有很大范围的改动,但在接下来的几个月内它们都是可逆的。在大多数情况下,从轻度和重度感染中恢复的患者的卵巢储备没有显着影响。除了一个,其中AMH水平显着降低,基础卵泡刺激素(FSH)水平升高。所有COVID-19康复患者的卵泡液中SARS-CoV-2IgG水平均为阳性。在三项研究中,回收和成熟卵母细胞的数量和受精率没有受到损害,除了一项研究,在SARS-CoV-2抗体水平较高的患者中,回收和成熟卵母细胞的数量减少。胚泡的数量,高质量的胚胎,在大多数综述的研究中,整倍体胚胎受到影响。
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