Abstract：
This nationwide, population-based, retrospective, matched case-control study included 111,960 newly diagnosed patients with scleritis who were identified by the International Classification of Diseases, Ninth Revision, Clinical Modification code 379.0, selected from the Taiwan National Health Insurance Research Database. Demographic characteristics, Sjögren syndrome, and comorbid conditions within 1 year before the scleritis diagnosis were examined using univariate logistic regression analyses, and a paired t-test was used for continuous variables. Adjusted logistic regression was used to compare the prognosis odds ratio (OR) of the patients with scleritis with the controls. After adjustment for confounders, patients with Sjögren syndrome were remarkably more likely to have scleritis than the controls (OR = 33.53, 95% confidence interval (CI) = 27.43-40.97, p < 0.001). Other conditions found to have increased odds of scleritis included post ocular pterygium, glaucoma, and scleral surgery (OR = 4.01, 95% CI = 3.64-4.43; OR = 3.16, 95% CI = 2.24-4.47; OR = 6.83, 95% CI = 5.34-8.74, respectively); systemic infections, such as syphilis, tuberculosis, and a human herpes viral infection (OR = 4.01, 95% CI = 2.93-5.50; OR = 2.24, 95% CI = 1.94-2.58; OR = 8.54, 95% CI = 8.07-9.03, respectively); and systemic diseases, such as rheumatoid arthritis, granulomatous vasculitis, systemic lupus erythematosus, ankylosing spondylitis, and gout (OR = 2.93, 95% CI = 2.66-3.23; OR = 7.37, 95% CI = 3.91-13.88; OR = 3.18, 95% CI = 2.63-3.85; OR = 5.57, 95% CI = 4.99-6.22; OR = 2.84, 95% CI = 2.72-2.96, respectively). The results strongly support an association between Sjögren syndrome, post ocular surgery, systemic infection disease, systemic autoimmune disease, and scleritis.
摘要：
这个全国范围内,以人口为基础,回顾性,匹配的病例对照研究包括111,960例新诊断的巩膜炎患者，这些患者由国际疾病分类鉴定，第九次修订,临床修改代码379.0，选自台湾国民健康保险研究数据库。人口特征，干燥综合征,使用单变量逻辑回归分析检查巩膜炎诊断前1年内的合并症，连续变量采用配对t检验。使用调整后的逻辑回归比较巩膜炎患者与对照组的预后优势比（OR）。在对混杂因素进行调整后，干燥综合征患者的巩膜炎发生率明显高于对照组(OR=33.53,95%置信区间(CI)=27.43~40.97,p<0.001).其他发现巩膜炎几率增加的疾病包括眼翼状胬肉后，青光眼,和巩膜手术（OR=4.01，95％CI=3.64-4.43；OR=3.16，95％CI=2.24-4.47；OR=6.83，95％CI=5.34-8.74）；全身感染，比如梅毒,结核病,和人类疱疹病毒感染（OR=4.01，95％CI=2.93-5.50；OR=2.24，95％CI=1.94-2.58；OR=8.54，95％CI=8.07-9.03）；和全身性疾病，比如类风湿性关节炎，肉芽肿性血管炎,系统性红斑狼疮,强直性脊柱炎,和痛风（OR=2.93，95％CI=2.66-3.23；OR=7.37，95％CI=3.91-13.88；OR=3.18，95％CI=2.63-3.85；OR=5.57，95％CI=4.99-6.22；OR=2.84，95％CI=2.72-2.96）。结果强烈支持干燥综合征之间的关联，眼科手术后，全身性感染疾病，全身性自身免疫性疾病，和巩膜炎.
